Oocyte environment: follicular fluid and cumulus cells are critical for oocyte health
Oocyte environment: follicular fluid and cumulus cells are critical for oocyte health
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DOI：
10.1016/j.fertnstert.2014.11.015
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发表时间：
2015-02-01
影响因子：
6.7
通讯作者：
Schoolcraft, William B.
中科院分区：
文献类型：
--
作者：
Dumesic, Daniel A.;Meldrum, David R.;Schoolcraft, William B.
双向体细胞-卵母细胞信号传导对于创造一个不断变化的卵泡内微环境至关重要，该微环境控制原始卵泡生长成一组生长卵泡，从中选择一个有腔卵泡排卵健康的卵母细胞。这种细胞间通讯允许卵母细胞通过影响卵泡内微环境来决定其自身的命运，这反过来为卵母细胞发育能力提供必要的细胞功能，卵母细胞发育能力被定义为卵母细胞完成减数分裂并经历受精、胚胎发生和足月发育的能力。这些协调的体细胞-卵母细胞相互作用试图在卵泡发生期间平衡细胞代谢与能量需求，包括在减数分裂恢复期间改变能量利用。如果这些细胞机制受到代谢疾病和/或母体衰老的干扰，卵母细胞的分子损伤可以改变大分子，诱导线粒体突变，并减少三磷酸腺苷的产生，所有这些都可以损害卵母细胞。最近的技术正在探索人类卵泡内的转录，翻译和翻译后事件，目的是确定在临床环境中可靠预测卵母细胞质量的生物标志物。(C)2015年，美国生殖医学会（American Society for Reproductive Medicine）
Bidirectional somatic cell-oocyte signaling is essential to create a changing intrafollicular microenvironment that controls primordial follicle growth into a cohort of growing follicles, from which one antral follicle is selected to ovulate a healthy oocyte. Such intercellular communications allow the oocyte to determine its own fate by influencing the intrafollicular microenvironment, which in turn provides the necessary cellular functions for oocyte developmental competence, which is defined as the ability of the oocyte to complete meiosis and undergo fertilization, embryogenesis, and term development. These coordinated somatic cell-oocyte interactions attempt to balance cellular metabolism with energy requirements during folliculogenesis, including changing energy utilization during meiotic resumption. If these cellular mechanisms are perturbed by metabolic disease and/or maternal aging, molecular damage of the oocyte can alter macromolecules, induce mitochondrial mutations, and reduce adenosine triphosphate production, all of which can harm the oocyte. Recent technologies are now exploring transcriptional, translational, and post-translational events within the human follicle with the goal of identifying biomarkers that reliably predict oocyte quality in the clinical setting. (C) 2015 by American Society for Reproductive Medicine.