Subgenual prefrontal cortex volumes in major depressive disorder and schizophrenia: Diagnostic specificity and prognostic implications
Subgenual prefrontal cortex volumes in major depressive disorder and schizophrenia: Diagnostic specificity and prognostic implications
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DOI：
10.1176/appi.ajp.162.9.1706
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发表时间：
2005-09-01
影响因子：
17.7
通讯作者：
Andreasen, NC
中科院分区：
文献类型：
--
作者：
Coryell, W;Nopoulos, P;Andreasen, NC
目的：各种研究结果表明，胼胝体腹侧的前扣带皮层部分在家族性抑郁症的病理生理学中起作用。有，到目前为止，很少有数据来解决这些异常抑郁症的特异性或表征其随时间的稳定性。方法：作者研究了10名被判定患有重度抑郁症伴精神病特征的受试者，他们接受了磁共振成像（MRI）方案，并参加了近期发作精神病的纵向研究。这些组匹配的10名精神分裂症患者和10名良好的比较对象。这30名受试者的膝下前额叶皮质的后部和前部的体积测量。随访扫描做了平均4年后的摄入量可用于7例重度抑郁症，9例精神分裂症，和5个以及比较subjects.Results：左侧的后膝下前额叶皮层的不同显着的组和最小的精神病性重度抑郁症组。前膝下前额叶皮层的神经活动在各组之间没有显著差异。重度抑郁症患者更有可能表现出增加后膝下前额叶皮质体积的后续比较科目或patients with schizophrenia.Conclusions：这些研究结果增加了证据表明，在前扣带回的膝下区域的异常至少在某些类型的情绪障碍中发挥作用。
Objective: A variety of findings have implicated the portion of the anterior cingulate cortex ventral to the corpus callosum in the pathophysiology of familial depressive disorder. There are, as yet, few data to address the specificity of these abnormalities to depressive disorders or to characterize their stability over time. Method: The authors studied 10 subjects who were judged to have had major depressive disorder with psychotic features, who underwent magnetic resonance imaging (MRI) protocols, and who participated in a longitudinal study of recent-onset psychosis. These were group-matched to 10 subjects with schizophrenia and to 10 well comparison subjects. Volumetric measures were made of the posterior and anterior portions of the subgenual prefrontal cortex for these 30 subjects. Followup scans done an average of 4 years after intake were available for seven subjects with major depressive disorder, nine subjects with schizophrenia, and five well comparison subjects.Results: Volumes of the left side of the posterior subgenual prefrontal cortex differed significantly by group and were smallest for the group with psychotic major depressive disorder. Volumes of the anterior subgenual prefrontal cortex did not differ significantly by group. Patients with major depressive disorder were more likely to show increases in posterior subgenual prefrontal cortex volume on follow-up than were comparison subjects or patients with schizophrenia.Conclusions: These findings add to the evidence that abnormalities in the subgenual region of the anterior cingulate play a role in at least some types of mood disorder.