THE IMPACT OF FAMILY HISTORY ON OVARIAN-CANCER RISK - THE UTAH POPULATION DATABASE
THE IMPACT OF FAMILY HISTORY ON OVARIAN-CANCER RISK - THE UTAH POPULATION DATABASE
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DOI：
10.1001/archinte.155.9.905
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发表时间：
1995-05-08
影响因子：
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通讯作者：
SLATTERY, ML
中科院分区：
文献类型：
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作者：
KERBER, RA;SLATTERY, ML
目的：估计卵巢癌的相对风险和人口归因于风险与癌症家族史在几个sites.Methods：匹配的病例对照分析研究（662例，2647对照），采用犹他州人口数据库，家谱约100万人与癌症发病率数据从犹他州癌症登记。家族史进行了评估，使用亲属顺序和亲属加权的家庭标准化发病率statistics.Results：卵巢癌，子宫癌，乳腺癌和胰腺癌的家族史与卵巢癌的风险增加显着相关。卵巢癌的相对危险度为4.31（95%置信区间[CI]，2.35至7.90）对于一级女性：与卵巢癌相关，2.12（95% CI，1.19至3.78）的女性与受影响的二级亲属，和1.48（95% CI，0.98至2.24）的女性与受影响的三级亲属。家族标准化发病率最高者的优势比（OR）为2.06（95%CI，1.44 ~ 2.93）。在有和没有卵巢癌家族史的病例之间没有观察到年龄差异。细胞类型的家族史效应存在实质性异质性。在所研究的地点，增加产次对有强烈癌症家族史的妇女没有保护作用（OR，1.11; 95%CI，0.38至3.26），尽管它在没有这些癌症家族史的女性中具有保护作用（OR，0.29; 95%CI，0.11至0.62）。有卵巢癌、子宫癌、胰腺癌家族史的妇女患卵巢癌的危险性显著增加，乳腺癌的危险性较小。在有任何这些癌症家族史的女性中，卵巢癌的风险不会因高产次而降低。
Objective: To estimate the relative risks and population attributable risks of ovarian cancer associated with family histories of cancer at several sites.Methods: A matched case-control analytic study (662 cases, 2647 controls), employing the Utah Population Database, a genealogy of approximately 1 million individuals linked to cancer incidence data from the Utah Cancer Registry. Family history was assessed using kinship order and a kinship-weighted familial standardized incidence ratio statistic.Results: Family histories of ovarian, uterine, breast, and pancreatic cancer were significantly associated with increased risk of ovarian cancer. The relative risk of ovarian cancer was 4.31 (95% confidence interval [CI], 2.35 to 7.90) for women with a first-degree: relative with ovarian cancer, 2.12 (95% CI, 1.19 to 3.78) for women with an affected second-degree relative, and 1.48 (95% CI, 0.98 to 2.24) for women with an affected third-degree relative. The odds ratio (OR) was 2.06 (95% CI, 1.44 to 2.93) for those with the highest familial standardized incidence ratio. No age differences were observed between cases with and without a family history of ovarian cancer. There was substantial heterogeneity of family history effects by cell type. Increased parity was not protective among women with a strong family history of cancer at the sites studied (OR, 1.11; 95% CI, 0.38 to 3.26), although it was protective among women without a family history of these cancers (OR, 0.29; 95% CI, 0.11 to 0.62).Conclusions: The risk of ovarian cancer was substantially increased among women with family histories of ovarian, uterine, pancreatic, and, to a lesser degree, breast cancer. Among women with family histories of any of these cancers, the risk of ovarian cancer is not diminished by high parity.