Neuropsychological function and apolipoprotein E genotype in the preclinical detection of Alzheimer's disease.
Neuropsychological function and apolipoprotein E genotype in the preclinical detection of Alzheimer's disease.
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DOI：
10.1037//0882-7974.14.2.295
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发表时间：
1999-06
影响因子：
3.7
通讯作者：
M. Bondi;David P. Salmon;Douglas R. Galasko;R. G. Thomas;L. Thal
中科院分区：
文献类型：
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作者：
M. Bondi;David P. Salmon;Douglas R. Galasko;R. G. Thomas;L. Thal
非痴呆老年人载脂蛋白E（ApoE）ε 4等位基因基因分型（n = 43）与无ε 4等位基因拷贝的参与者（n = 90）进行神经心理学比较。在基线时，各组在年龄、教育、性别或整体认知状态方面没有差异。ApoE ε 4参与者在延迟回忆方面表现出显著较差的平均表现，但在注意力、语言、构建技能、心理速度或执行功能方面没有显著的组间差异。与非ε 4受试者相比，ApoE ε 4受试者发生可能或可疑阿尔茨海默病（AD）的人数明显更多，这表明组间差异是由于ε 4组内临床前AD病例占优势，而不是ApoE基因型对认知的直接影响。调整年龄、受教育年限和整体认知状态后的考克斯比例风险分析显示，ApoE ε 4等位基因状态和回忆表现指标是转换为AD的显著独立预测因子。结果支持特定情景记忆变化和ApoE-ε 4等位基因在AD临床前检测中的重要性。
Nondemented older adults genotyped for the Apolipoprotein E (ApoE) epsilon4 allele (n = 43) were neuropsychologically compared to participants without a copy of the epsilon4 allele (n = 90). At baseline, the groups did not differ on age, education, gender, or global cognitive status. ApoE-epsilon4 participants demonstrated significantly poorer mean performances on delayed recall, but no significant group differences emerged on attention, language, constructional skills, psychomotor speed, or executive function. Significantly more ApoE-epsilon4 participants developed probable or questionable Alzheimer's disease (AD) compared with non-epsilon4 participants, suggesting that the group differences resulted from a preponderance of preclinical AD cases within the epsilon4 group and not from a direct influence of ApoE genotype on cognition. Cox proportional hazards analysis, adjusting for age, years of education, and global cognitive status, revealed that ApoE-epsilon4 allele status and measures of recall performance were significant and independent predictors of conversion to AD. Results support the importance of specific episodic memory changes and possession of the ApoE-epsilon4 allele in the preclinical detection of AD.