Effects of melatonin, testosterone and the two hormones administered in parallel on epididymis of the rat estrogenized with stilbestrol in the first day of life.
Effects of melatonin, testosterone and the two hormones administered in parallel on epididymis of the rat estrogenized with stilbestrol in the first day of life.
复制标题
褪黑激素、睾酮和两种激素同时给药对出生第一天用己烯雌酚雌激素化的大鼠附睾的影响。
DOI：
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发表时间：
1996
影响因子：
2
通讯作者：
B. Otulakowski
中科院分区：
文献类型：
--
作者：
A. Limanowski;B. Miśkowiak;B. Otulakowski
在出生第一天给大鼠单剂量 1 mg 己烯雌酚，测试褪黑激素、睾酮以及同时给予的两种激素对大鼠附睾的影响。从出生第 20 天或第 28 天开始，每天注射激素，持续 39 天。当大鼠达到成熟年龄（59或67天）时，单剂量雌激素治疗导致附睾萎缩，并伴有腺上皮及其间质的变化。在这些大鼠中，LH 促性腺激素水平升高，睾酮水平降低。服用褪黑激素未能影响雌激素治疗引起的变化。单独施用睾酮或睾酮与褪黑激素同时施用导致附睾状态与对照动物中所见的更加相似。睾丸传出小管（附睾头）也被证明比附睾管（附睾体和尾部）对所执行的实验程序更敏感。
Effect of melatonin, testosterone and of both hormones given in parallel on rat epididymis was tested in rats given a single dose of 1 mg stilbestrol on the first day of the life. The hormones were given daily for 39 days, beginning from the 20th or 28th day of life. The single dose of estrogen treatment resulted in epididymis atrophy, accompanied by changes in glandular epithelium and in its stroma, when the rats reached mature age (59 or 67 days of life). In such rats, LH gonadotropin level was elevated and testosterone level was decreased. Administration of melatonin failed to affect the changes induced by estrogen treatment. Administration of testosterone alone or of testosterone in parallel with melatonin caused the epididymis status to resemble more closely that seen in control animals. Efferent ductules of the testis (head of epididymis) were also demonstrated to be more sensitive to the performed experimental procedures than the duct of the epididymis (body and tail of the epididymis).
雌激素和雄激素对未成熟兔附睾蛋白质合成的调节。
影响因子：
4.8
作者：
Toney,TW;Danzo,BJ
通讯作者：
Danzo,BJ