Correlates of lipoprotein(a) levels in a biracial cohort of young girls: the NHLBI Growth and Health Study.
Correlates of lipoprotein(a) levels in a biracial cohort of young girls: the NHLBI Growth and Health Study.
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混血儿年轻女孩中脂蛋白 (a) 水平的相关性：NHLBI 生长与健康研究。
DOI：
10.1016/s0022-3476(99)70018-1
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Ferrell,RE
中科院分区：
文献类型：
--
作者：
Kimm,SY;Pasagian-Macaulay,A;Aston,CE;McAllister,AE;Glynn,NW;Kamboh,MI;Ferrell,RE
脂蛋白(a) [Lp(a)]水平升高与冠心病（CHD）风险增加有关。然而，在Lp(a)水平及其相关的冠心病风险上观察到种族差异，非洲裔美国人的Lp(a)水平平均高于美国白人，但冠心病风险没有预期的增加。我们在国家心脏、肺和血液研究所的一项肥胖发展纵向研究的基线访问中，测定了9至10岁黑人和白人女孩（n = 2379）的Lp(a)水平及其相关因素。1269名女孩可获得Lp(a)水平。黑人女孩的中位Lp(a)水平比白人女孩高出3倍以上。研究了Lp(a)水平与低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇、载脂蛋白B、甘油三酯、肥胖、青春期成熟阶段、体脂模式（肱三头肌/躯干皮褶比）和膳食脂肪（Keys’score）之间的关系。在黑人女孩中，多元回归分析发现LDL-C （P < .001）和肥胖（P = .08）是Lp(a)水平的预测因子。在白人女孩中，只有LDL-C （P = 0.02）与Lp(a)相关。综上所述，黑人女孩血清Lp(a)水平显著高于黑人女孩。我们的研究还揭示了Lp(a)相关因素的种族差异，如LDL-C和肥胖。这种种族差异是由于潜在的生物学差异，还是仅仅反映了更大的统计能力来检测与水平的关系，黑人女孩的水平比白人女孩高2.5倍，需要进一步的研究。[J]儿科杂志1999；135:169-76。
Elevated levels of lipoprotein(a) [Lp(a)] are associated with increased risk for coronary heart disease (CHD). However, racial differences in both Lp(a) levels and their associated CHD risk are observed, with African Americans having, on average, higher Lp(a) levels than US whites but not the expected increase in CHD risk. We determined Lp(a) levels and their correlates in a large cohort (n = 2379) of black and white girls, ages 9 to 10 years, at the baseline visit of a longitudinal study of obesity development, the National Heart, Lung, and Blood Institute Growth and Health Study. Lp(a) levels were available for 1269 girls. The median Lp(a) level in black girls was over 3-fold higher than that in white girls. Associations were examined between Lp(a) levels and low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol, apolipoprotein B, triglycerides, adiposity, pubertal maturation stage, body fat patterning (triceps/truncal skinfold ratio), and dietary fat (Keys’ score). In black girls multiple regression analysis identified LDL-C (P < .001) and adiposity (P = .08) as predictors of Lp(a) levels. In white girls only LDL-C (P = .02) was associated with Lp(a). In conclusion, the level of Lp(a) was significantly higher in black girls. Our study also revealed a racial difference in correlates of Lp(a), such as LDL-C and adiposity. Whether this racial difference is due to an underlying biologic difference or is merely a reflection of a greater statistical power to detect a relationship with the level, which was 2.5-fold higher in black girls than in white girls, needs further investigation. (J Pediatr 1999;135:169-76)