PARAMETRIC INVESTIGATIONS OF EFFECTS OF PRIOR EXPOSURE TO AMPHETAMINE AND MORPHINE ON CONDITIONED GUSTATORY AVERSION
PARAMETRIC INVESTIGATIONS OF EFFECTS OF PRIOR EXPOSURE TO AMPHETAMINE AND MORPHINE ON CONDITIONED GUSTATORY AVERSION
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DOI：
10.1007/bf00431634
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发表时间：
1977-01-01
影响因子：
3.4
通讯作者：
LEBLANC, AE
中科院分区：
文献类型：
--
作者：
CAPPELL, H;LEBLANC, AE
用精神活性药物进行预处理可以大大减弱该药物对味觉回避的调节作用。尽管这些发现已被解释为耐受性，但其他解释也是可能的。以 24 小时为间隔使用吗啡或安非他明进行预处理，在减弱调节方面并不比以 120 小时为间隔进行的预处理更有效，但在之前的类似实验中，吗啡或安非他明预处理本身比安非他明提供了更持久的保护，以防止随后的调节。集中和间隔预处理效果的相似性可以在不将耐受性作为一个因素的情况下进行解释，但吗啡预处理的更大持久性暗示了耐受性作为一种机制。
Pretreatment by a psychoactive drug can greatly attenuate the conditioning of gustatory avoidance by that drug. Although such findings have been interpreted in terms of tolerance, alternative explanations are possible. Pretreatments with morphine or amphetamine massed at 24-h intervals were no more effective in attenuating conditioning than pretreatments spaced at 120-h intervals, but pretreatment with morphine provided more persistent protection against subsequent conditioning by itself than did amphetamine in a comparable previous experiment. The similarity of massed and spaced pretreatment effects can be interpreted without appealing to tolerance as a factor, but the greater persistence of morphine pretreatment implicates tolerance as a mechanism.