Oligoclonality of CD8+ T cells in health and disease: Aging, infection, or immune regulation?
Oligoclonality of CD8+ T cells in health and disease: Aging, infection, or immune regulation?
复制标题
DOI：
10.1016/0198-8859(96)00077-8
复制
发表时间：
1996-06-01
期刊：
影响因子：
2.7
通讯作者：
Gregersen, PK
中科院分区：
文献类型：
--
作者：
Batliwalla, F;Monteiro, J;Gregersen, PK
CD 8 + T细胞亚群的寡克隆性是正常人外周T细胞库的常见特征。这些克隆扩增的群体主要存在于CD 57+或CD 28-CD 8 + T细胞亚群中。虽然CD 8寡克隆性在老年组中更为常见，但在年轻至中年成人中也非常普遍。最近的实验还表明，克隆扩增的群体实际上可能发生在两个不同的CD 8 + CD 28-细胞亚群中，其通过CD 57表面标志物的表达来区分。涉及CD 8 + CD 28-CD 57 + T细胞的研究的主要困难是它们相对缺乏增殖能力。我们最近研究了这种表型在某些情况下可能是由于“复制性衰老”状态的可能性。在这方面，我们已经证明，CD 8 + CD 28- T细胞的端粒长度通常比它们的CD 8 + CD 28+对应物短，这与CD 8 + CD 28-群体的独特复制历史一致。对克隆扩增的CD 8 + T细胞的正常生物学的进一步研究可能会对健康和疾病中的免疫功能产生重要的见解。
Oligoclonality of the CD8+ T cell subset is a common and characteristic feature of the normal human peripheral T cell repertoire. These clonally expanded populations are predominantly found in a CD57+ or CD28- CD8+ T cell subset. While CD8 oligoclonality is somewhat more common in the older age group, it is also very prevalent in young to middle-aged adults. Recent experiments have also demonstrated that the clonally expanded populations may actually occur in two distinct subpopulations of CD8+ CD28- cells, distinguished by the expression of the CD57 surface marker, A major difficulty with studies involving CD8+ CD28- CD57+ T cells is their relative lack of proliferative capacity. We have recently investigated the possibility that this phenotype may be due to a state of ''replicative senescence'' in some cases. In this regard, we have demonstrated that the telomere lengths of CD8+ CD28- T cells are generally shorter than that of their CD8+ CD28+ counterparts, consistent with a distinct replicative history for the CD8+ CD28- population. Additional studies of the normal biology of clonally expanded CD8+ T cells are likely to yield important insights into immune function in health and disease.