MESIOBASAL VERSUS LATERAL TEMPORAL-LOBE EPILEPSY - METABOLIC DIFFERENCES IN THE TEMPORAL-LOBE SHOWN BY INTERICTAL F-18 FDG POSITRON EMISSION TOMOGRAPHY
MESIOBASAL VERSUS LATERAL TEMPORAL-LOBE EPILEPSY - METABOLIC DIFFERENCES IN THE TEMPORAL-LOBE SHOWN BY INTERICTAL F-18 FDG POSITRON EMISSION TOMOGRAPHY
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DOI：
10.1212/wnl.43.1_part_1.79
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发表时间：
1993-01-01
期刊：
影响因子：
9.9
通讯作者：
WIESER, HG
中科院分区：
文献类型：
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作者：
HAJEK, M;ANTONINI, A;WIESER, HG
应用发作间期[F-18]-氟代脱氧葡萄糖(FDG)正电子发射断层扫描(PET)研究了25例起源于近基底或外侧的颞叶癫痫患者的颞叶代谢异常。20例患者采用发作期卵圆孔电极和头皮电极记录致痫灶，1例采用立体脑电图法。四名磁共振成像上有结构性病变的患者进行了非侵入性发作表面脑电记录。16例患者有明确的近基底位癫痫发作，5例癫痫发作起源于颞叶外侧新皮质。24例患者接受了择期手术。伴有近侧胶质细胞增生症的患者(n=15)的FDG摄取率在整个TL中最低，其次是起源于颞侧的患者(n=5)。位于近基底区的肿瘤患者(n=5)，总体上仅表现为所有TL结构中的葡萄糖代谢轻微下降。低代谢程度与脑电确定的致痫灶的位置之间没有明确的相关性。然而，代谢模式在患者组之间是不同的，并允许区分内侧和外侧颞叶癫痫发作的患者。
Metabolic abnormalities in the temporal lobe (TL) of 25 patients suffering from temporal lobe epilepsy of mesiobasal or lateral TL origin have been investigated using interictal [F-18]-fluorodeoxyglucose (FDG) positron emission tomography (PET). The epileptogenic area was determined by ictal EEG recordings using foramen ovale and scalp electrodes in 20 patients, and by the use of stereo-electroencephalography in one patient. Four patients with structural lesions on their MRIs had noninvasive ictal surface EEG recordings. Sixteen patients had a clear-cut mesiobasal seizure onset, and in five patients the seizures originated from the lateral temporal neocortex. Twenty-four patients underwent selective surgery. Patients with temporal limbic seizures associated with mesial gliosis (n = 15) had the lowest FDG uptake in the entire TL, followed by patients with lateral temporal seizure origin (n = 5). Patients with tumors located in the mesiobasal TL (n = 5) showed, in general, only a slight decrease of glucose metabolism in all TL structures. There was no clear-cut correlation between the degree of hypometabolism and the location of EEG-defined epileptogenic focus. The metabolic pattern, however, differed between the patient groups and allowed a discrimination between patients of mesial temporal and lateral temporal seizure onset.