Electrodeposited Platinum Iridium Enables Microstimulation With Carbon Fiber Electrodes
Electrodeposited Platinum Iridium Enables Microstimulation With Carbon Fiber Electrodes
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DOI：
10.3389/fnano.2021.782883
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发表时间：
2021-12-02
影响因子：
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通讯作者：
Weiland, James D.
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文献类型：
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作者：
della Valle, Elena;Koo, Beomseo;Weiland, James D.
超小型微电极阵列具有提高微刺激空间分辨率的潜力。在慢性植入试验中，横截面小于8微米的碳纤维(CF)微电极已被证明可以穿透皮质组织并引起最小的疤痕。在这项研究中，我们研究了在碳纤维上电沉积铂-铱(PTIR)组成的神经刺激电极的稳定性和性能。我们在体外进行了脉冲测试和电荷注入表征，并在体外和体内记录了电压瞬变。使用标准的电化学测量(阻抗谱和循环伏安法)和肉眼观察(扫描电子显微镜)来评估脉冲引起的变化。与其他研究类似，施加脉冲导致阻抗下降和电压瞬变减少，但对阻抗数据的分析表明，这些变化是由于表面修饰而不是对电极的永久性改变。对比脉冲测试前后的扫描电子显微镜图像，证实了电极的稳定性。
Ultrasmall microelectrode arrays have the potential to improve the spatial resolution of microstimulation. Carbon fiber (CF) microelectrodes with cross-sections of less than 8 mu m have been demonstrated to penetrate cortical tissue and evoke minimal scarring in chronic implant tests. In this study, we investigate the stability and performance of neural stimulation electrodes comprised of electrodeposited platinum-iridium (PtIr) on carbon fibers. We conducted pulse testing and characterized charge injection in vitro and recorded voltage transients in vitro and in vivo. Standard electrochemical measurements (impedance spectroscopy and cyclic voltammetry) and visual inspection (scanning electron microscopy) were used to assess changes due to pulsing. Similar to other studies, the application of pulses caused a decrease in impedance and a reduction in voltage transients, but analysis of the impedance data suggests that these changes are due to surface modification and not permanent changes to the electrode. Comparison of scanning electron microscope images before and after pulse testing confirmed electrode stability.