Use of magnetic resonance to study biodistribution of dextran-coated magnetic fluid intravenously administered in mice
Use of magnetic resonance to study biodistribution of dextran-coated magnetic fluid intravenously administered in mice
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DOI：
10.1016/s0304-8853(02)00654-6
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发表时间：
2002-11-01
影响因子：
2.7
通讯作者：
Morais, PC
中科院分区：
文献类型：
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作者：
Lacava, LM;Lacava, ZGM;Morais, PC
用核磁共振技术研究了葡聚糖包被的磁性纳米粒子(直径9.4 nm)静脉注射后在雌性瑞士小鼠体内的动力学分布和随后的生物分布。X波段光谱显示在g2附近有一条宽阔的单线，这是悬浮在非磁性基质中的纳米磁性粒子的典型特征。在最初的90min内，血液中纳米粒子浓度的时间衰减符合一指数(一室)模型，半衰期为6.9min。对于血液，从磁共振数据中获得清除量(90mul/min)和分布体积(900mul)。给药90min后，在肝和脾中发现了磁铁矿纳米颗粒，典型吸收半衰期为14min。(C)2002 Elsevier Science B.V.保留所有权利。
Magnetic resonance was used to investigate the kinetic disposition and the subsequent biodistribution of dextran-coated magnetite nanoparticles (9.4 nm core diameter) after intravenous injection of a bolus dose in female Swiss mice. The X-band spectra show a broad single-line at gapproximate to2, typical of nanomagnetic particles suspended in a non-magnetic matrix. In the first 90 min the time-decay of the nanoparticle concentration in the bloodstream follows the one-exponential (one-compartment) model with a half-life of 6.9 min. With respect to blood the clearance (90 mul/min) and the volume of distribution (900 mul) were obtained from the magnetic resonance data. Magnetite nanoparticles were found 90 min after administration in liver and spleen with a typical absorption half-life of 14 min. (C) 2002 Elsevier Science B.V. All rights reserved.