Gene regulation by long non-coding RNAs and its biological functions.
Gene regulation by long non-coding RNAs and its biological functions.
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长链非编码RNA的基因调控及其生物学功能。
DOI：
10.1038/s41580-020-00315-9
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Huarte M
中科院分区：
文献类型：
--
作者：
Statello L;Guo CJ;Chen LL;Huarte M
过去十年积累的证据表明，长非编码RNA(LncRNAs)广泛表达，并在基因调控中发挥关键作用。最近的研究已经开始揭示lncRNAs的生物发生如何不同于mRNAs，并与它们特定的亚细胞定位和功能联系在一起。根据它们的定位及其与DNA、RNA和蛋白质的特异性相互作用，lncRNAs可以调节染色质功能，调节无膜核体的组装和功能，改变细胞质mRNAs的稳定性和翻译，并干扰信号通路。这些功能中的许多最终会在不同的生物学和生理病理环境中影响基因的表达，例如在神经元疾病、免疫反应和癌症中。组织特异性和条件特异性表达模式表明，lncRNAs是潜在的生物标记物，并为临床靶向它们提供了理论基础。本文综述了lncRNA的生物发生机制、在转录、转录后和其他基因调控模式中的定位和功能，以及它们潜在的治疗应用。最近的研究为长非编码RNA(LncRNAs)的生物发生及其特定功能提供了新的见解。LncRNAs的功能从转录和转录后基因调控到无膜核体的组装和功能，与神经元疾病、免疫反应和癌症有关。
Evidence accumulated over the past decade shows that long non-coding RNAs (lncRNAs) are widely expressed and have key roles in gene regulation. Recent studies have begun to unravel how the biogenesis of lncRNAs is distinct from that of mRNAs and is linked with their specific subcellular localizations and functions. Depending on their localization and their specific interactions with DNA, RNA and proteins, lncRNAs can modulate chromatin function, regulate the assembly and function of membraneless nuclear bodies, alter the stability and translation of cytoplasmic mRNAs and interfere with signalling pathways. Many of these functions ultimately affect gene expression in diverse biological and physiopathological contexts, such as in neuronal disorders, immune responses and cancer. Tissue-specific and condition-specific expression patterns suggest that lncRNAs are potential biomarkers and provide a rationale to target them clinically. In this Review, we discuss the mechanisms of lncRNA biogenesis, localization and functions in transcriptional, post-transcriptional and other modes of gene regulation, and their potential therapeutic applications. Recent studies have provided novel insight into the biogenesis of long non-coding RNAs (lncRNAs) and their specific functions. The functions of lncRNAs vary from transcriptional and post-transcriptional gene regulation to the assembly and function of membraneless nuclear bodies, and are relevant to neuronal disorders, immune responses and cancer.
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DOI：
10.1007/s00018-014-1569-4
发表时间：
2014-07
期刊：
Cellular and molecular life sciences : CMLS
影响因子：
--
作者：
Bharti SK;Khan I;Banerjee T;Sommers JA;Wu Y;Brosh RM Jr
通讯作者：
Brosh RM Jr
影响因子：
16
作者：
Bosson, Andrew D.;Zamudio, Jesse R.;Sharp, Phillip A.
通讯作者：
Sharp, Phillip A.
影响因子：
16.6
作者：
Arora, Rajika;Lee, Yongwoo;Wischnewski, Harry;Brun, Catherine M.;Schwarz, Tobias;Azzalin, Claus M.
通讯作者：
Azzalin, Claus M.
RIC-seq 用于 RNA–RNA 空间相互作用的全局原位分析
影响因子：
64.8
作者：
Cai, Zhaokui;Cao, Changchang;Xue, Yuanchao
通讯作者：
Xue, Yuanchao
影响因子：
56.9
作者：
Azzalin, Claus M.;Reichenbach, Patrick;Lingner, Joachim
通讯作者：
Lingner, Joachim