Familial transmission of derived phenotypes for molecular genetic studies of substance use disorders
Familial transmission of derived phenotypes for molecular genetic studies of substance use disorders
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DOI：
10.1016/j.drugalcdep.2007.07.002
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发表时间：
2008-01-01
影响因子：
4.2
通讯作者：
Biederman, Joseph
中科院分区：
文献类型：
--
作者：
Faraone, Stephen V.;Adamson, Joel J.;Biederman, Joseph
尽管家庭、双胞胎和收养研究表明，基因在物质使用障碍（SUD）的发展中起着重要的病因学作用，但由于如何定义SUD、遗传异质性和SUD基因型的可变表型表达的不确定性，检测特定基因一直很困难。我们使用了六项儿童和成人同期研究中招募的家庭数据，使用主因子因子分析和变异旋转来获得候选SUD表型。我们之前在后代中发现了两种SUD表型的证据：精神病理维度和认知障碍维度。我们在成人中发现了一种与sud相关的表型的证据，我们称之为精神病理学和认知障碍。亲本因子得分对子代表型、亲本SUD （OR = 1.41, p < 0.001）和子代SUD（母亲表型：OR = 1.34, p = 0.04；父亲表型：OR = 1.33, p = 0.01）均有显著预测作用。后代表型预测后代SUD（精神病理表型：OR = 2.96, p < 0.001；认知功能障碍：OR = 1.33, p = 0.04）；在后代中，基线精神病理学预测随访评估中的SUD （OR = 1.55, p = 0.01）。结果表明，这些候选SUD表型可能对SUD的遗传研究有用。2007爱思唯尔爱尔兰有限公司版权所有。
Although family, twin, and adoption studies indicate that genes play a significant etiologic role in the development of substance use disorders (SUDs), detecting specific genes has been difficult due to uncertainties about how to define SUDs, genetic heterogeneity and variable phenotypic expression of SUD genotypes. We used data from families recruited into six contemporaneous studies of children and adults to derive candidate SUD phenotypes using principle factors factor analysis with varimax rotation. We previously found evidence of two SUD phenotypes in offspring: a psychopathology dimension and a cognitive impairment dimension. We found evidence for one SUD-related phenotype in adults that we term Psychopathology and Cognitive Impairment. Parental factor scores significantly predicted both offspring phenotypes, as well as parental SUD (OR = 1.41, p < 0.001) and offspring SUD (mother's phenotype: OR = 1.34, p = 0.04; father's phenotype: OR = 1.33, p = 0.01). Offspring phenotype predicted offspring SUD (psychopathology phenotype: OR = 2.96, p < 0.001; cognitive impairment: OR = 1.33, p = 0.04); in offspring, baseline psychopathology predicted SUD at follow-up assessments (OR = 1.55, p = 0.01). Results suggest that these candidate SUD phenotypes may be useful for genetic studies of SUD. (C) 2007 Elsevier Ireland Ltd. All rights reserved.