Amiodarone-induced keratopathy in healthy dogs
Amiodarone-induced keratopathy in healthy dogs
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DOI：
10.1046/j.1463-5224.2002.00208.x
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发表时间：
2002-03-01
影响因子：
1.6
通讯作者：
Hamlin, RL
中科院分区：
文献类型：
--
作者：
Bicer, S;Fuller, GA;Hamlin, RL
胺碘酮是一种广谱的抗心律失常药物，适用于心房和室性心律失常患者。胺碘酮引起的角膜沉积是人类最常见的可逆副作用（70-100%）。对人类的其他眼部影响包括晶状体、视网膜和视神经的沉积。本研究旨在确定健康犬长期口服胺碘酮对眼部的影响。6只患有慢性疾病的狗和4只对照狗被用于这项研究。在给药第4、7、11周末采用生物显微镜和间接眼科检查。第7周末和第11周末，一只眼和另一只眼均有角膜微沉积。在安乐死后，角膜和视神经立即被采集用于光镜和电子显微镜分析。光镜分析显示，临床患病犬角膜基底上皮细胞有角膜沉积。此外，与未沉积胺碘酮组和对照组相比，观察到受影响犬的基底细胞周转率显著增加，如有丝分裂指数所示。其余的动物都很正常。6只接受胺碘酮治疗的狗中有1只出现角膜沉积（16%）。与人类相比，这种发病率很低。对此的解释可能包括物种差异，特别是泪液分泌量的差异，或者需要更长的给药时间。此外，它被认为会加剧人类的角膜沉积，在这项研究中，所有的狗都被关在室内。
Amiodarone has a broad spectrum as an antiarrhythmic agent and is indicated for patients with atrial and ventricular arrhythmias. Amiodarone-induced corneal deposits are the most common reversible side effect (70-100%) in humans. Additional ocular effects in humans include deposits in the lens, retina and optic nerve. This study was conducted to determine ocular effects of chronic oral amiodarone in healthy dogs. Six chronically dogs and four controls were used for this study. Ophthalmic examination was performed using biomicroscopy and indirect ophthalmoscopy at the end of 4th, 7th and 11th weeks dogs received amiodarone. Corneal microdeposits were observed at the end of the 7th in one eye and at end of the 11th week in the other eye of one dog. Immediately following euthanasia, corneas and optic nerves were harvested for light and electron microscopic analysis. Light microscopic analysis showed corneal deposits in the basal epithelial cells of the cornea of the clinically affected dog. In addition, a significant increase in basal cell turnover as indicated by mitotic index was observed in the affected dog compared to both nondeposit amiodarone and control groups. Ail remaining animals were normal. One out six dogs treated with amiodarone demonstrated corneal deposits (16%). This prevalence is low compared to humans. Explanations for this may include species variations Particularly in volume of lacrimal secretion, or the need for longer administration. In addition, is believed to exacerbate the corneal deposits in humans and all dogs in this study were housed indoors.