Common KIBRA alleles are associated with human memory performance
Common KIBRA alleles are associated with human memory performance
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DOI：
10.1126/science.1129837
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发表时间：
2006-10-20
期刊：
影响因子：
56.9
通讯作者：
de Quervain, Dominique J. -F.
中科院分区：
文献类型：
--
作者：
Papassotiropoulos, Andreas;Stephan, Dietrich A.;de Quervain, Dominique J. -F.
人类的记忆是一种多基因特征。我们进行了全基因组筛查，以识别与记忆相关的基因变体。在来自瑞士和美国的三个独立的、认知正常的队列中，编码大脑蛋白Kibra的基因组基因座与记忆表现显著相关。基因表达研究表明Kibra在与记忆相关的大脑结构中表达。功能磁共振成像检测到记忆提取过程中海马区激活的Kibra等位基因依赖的差异。这些实验的证据表明Kibra在人类记忆中扮演着一个角色。
Human memory is a polygenic trait. We performed a genome-wide screen to identify memory-related gene variants. A genomic locus encoding the brain protein KIBRA was significantly associated with memory performance in three independent, cognitively normal cohorts from Switzerland and the United States. Gene expression studies showed that KIBRA was expressed in memory-related brain structures. Functional magnetic resonance imaging detected KIBRA allele dependent differences in hippocampal activations during memory retrieval. Evidence from these experiments suggests a role for KIBRA in human memory.