Neuroimaging studies in post-traumatic stress disorder.
Neuroimaging studies in post-traumatic stress disorder.
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DOI：
10.1007/s11920-996-0044-9
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发表时间：
2002-08-01
影响因子：
6.7
通讯作者：
Bremner, J Douglas
中科院分区：
文献类型：
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作者：
Bremner, J Douglas
在过去的十年中，人们对创伤后应激障碍（PTSD）的神经回路的理解取得了迅速的进展，这在很大程度上是由于神经影像学在这种疾病研究中的应用。基于对压力对大脑影响的动物研究，内侧前额皮质、海马体和杏仁核的功能障碍被假设为创伤后应激障碍症状的基础。创伤后应激障碍的神经影像学研究与这些假设一致，大多数重复的发现显示创伤后应激障碍的内侧前额皮质功能下降。其他重复的发现包括额下回功能下降，海马功能下降，后扣带功能增加，在某些行为范式中，杏仁核功能增加。一些研究已经表明，创伤后应激障碍患者海马体的结构发生了变化（体积变小）。这些研究开始描绘出创伤后应激障碍的神经回路，这可能对未来的诊断和治疗有影响。
The past decade has seen a rapid advance in understanding of the neural circuits of post-traumatic stress disorder (PTSD), which has largely been due to the application of neuroimaging to the study of this disorder. Based on studies in animals of the effects of stress on the brain, dysfunction of the medial prefrontal cortex, hippocampus, and amygdala have been hypothesized to underlie symptoms of PTSD. Neuroimaging studies in PTSD have been consistent with these hypotheses, with the most replicated findings showing decreased medial prefrontal cortical function in PTSD. Other replicated findings include decreased inferior frontal gyrus function, decreased hippocampal function, increased posterior cingulate function, and, in some behavioral paradigms, increased amygdala function. Several studies have now shown changes in structure (smaller volume) of the hippocampus in PTSD. These studies are beginning to map out a neural circuitry of PTSD that may have future implications for diagnosis and treatment.