Normative Values of Cognitive and Physical Function in Older Adults: Findings from The Irish Longitudinal Study on Ageing
Normative Values of Cognitive and Physical Function in Older Adults: Findings from The Irish Longitudinal Study on Ageing
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DOI：
10.1111/jgs.12195
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发表时间：
2013-05-01
影响因子：
6.3
通讯作者：
Savva, George M.
中科院分区：
文献类型：
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作者：
Kenny, Rose Anne;Coen, Robert F.;Savva, George M.
目的提供认知和身体功能测试的标准值的基础上，一个大的样本代表人口的爱尔兰50岁及以上。设计数据来自爱尔兰老龄化纵向研究（TILDA）的第一波，这是一项前瞻性队列研究，包括全面的健康评估。健康评估在两个专门的健康评估中心之一进行，如果旅行不可行，则在研究参与者的家中进行。参与者5897名成员的一个全国代表性的样本社区生活人口的爱尔兰50岁及以上。那些有严重认知障碍、痴呆或帕金森病的人被排除在外。测量指标包括身高和体重、正常步行速度、定时起身行走、握力、简易精神状态检查（MMSE）、蒙特利尔认知评估（莫卡）、颜色轨迹测试和骨密度。使用位置、形状和尺度的广义加性模型（GAMLSS）估计标准值，并表示为平均值、平均值和标准差。结果位置、形状和尺度的广义加性模型对各指标的观测数据拟合良好，得到了可靠的标准值估计。所有任务的表现都随着年龄的增长而下降。受教育程度是所有认知测试表现的重要决定因素。步行速度的测试取决于身高。由于体重和身高同时下降，体重指数的分布并不随年龄而变化。结论正常值被发现测试的认知和身体功能的许多方面的基础上，一般老年爱尔兰人口的代表性样本。
Objectives To provide normative values of tests of cognitive and physical function based on a large sample representative of the population of Ireland aged 50 and older. Design Data were used from the first wave of The Irish Longitudinal Study on Ageing (TILDA), a prospective cohort study that includes a comprehensive health assessment. Setting Health assessment was undertaken at one of two dedicated health assessment centers or in the study participant's home if travel was not practicable. Participants Five thousand eight hundred ninety-seven members of a nationally representative sample of the community-living population of Ireland aged 50 and older. Those with severe cognitive impairment, dementia, or Parkinson's disease were excluded. Measurements Measurements included height and weight, normal walking speed, Timed Up-and-Go, handgrip strength, Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Color Trails Test, and bone mineral density. Normative values were estimated using generalized additive models for location shape and scale (GAMLSS) and are presented as percentiles, means, and standard deviations. Results Generalized additive models for location shape and scale fit the observed data well for each measure, leading to reliable estimates of normative values. Performance on all tasks decreased with age. Educational attainment was a strong determinant of performance on all cognitive tests. Tests of walking speed were dependent on height. Distribution of body mass index did not change with age, owing to simultaneous declines in weight and height. Conclusion Normative values were found for tests of many aspects of cognitive and physical function based on a representative sample of the general older Irish population.