Optimizing IGF-I for skeletal muscle therapeutics.
Optimizing IGF-I for skeletal muscle therapeutics.
复制标题
DOI：
10.1016/j.ghir.2014.06.003
复制
发表时间：
2014-10
期刊：
影响因子：
--
通讯作者：
Barton ER
中科院分区：
文献类型：
--
作者：
Philippou A;Barton ER
igf - 1促进细胞生长和存活几乎是无可争议的。然而，多种IGF-I亚型、大量细胞内信号成分和多种受体的存在导致了一个复杂且高度调控的系统，IGF-I的作用是通过该系统介导的。igf - 1一直被认为是协调肌肉生长、促进肌肉修复、增加肌肉质量和力量的关键因素之一。如何优化这一系列途径来驱动肌肉中的合成代谢过程，而不是其他组织中的异常生长，是一个值得关注的领域。本文将讨论igf - 1的生物利用度、效力和组织反应方面的进展如何为骨骼肌治疗提供新的潜在方向。
It is virtually undisputed that IGF-I promotes cell growth and survival. However, the presence of several IGF-I isoforms, vast numbers of intracellular signaling components, and multiple receptors results in a complex and highly regulated system by which IGF-I actions are mediated. IGF-I has long been recognized as one of the critical factors for coordinating muscle growth, enhancing muscle repair, and increasing muscle mass and strength. How to optimize this panoply of pathways to drive anabolic processes in muscle as opposed to aberrant growth in other tissues is an area that deserves focus. This review will address how advances in the bioavailability, potency, and tissue response of IGF-I can provide new potential directions for skeletal muscle therapeutics.