Decline in beta adrenergic receptor-mediated vascular relaxation with aging in man.
Decline in beta adrenergic receptor-mediated vascular relaxation with aging in man.
复制标题
随着人类衰老，β 肾上腺素能受体介导的血管舒张能力下降。
DOI：
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发表时间：
1986
影响因子：
3.5
通讯作者：
T. Blaschke
中科院分区：
文献类型：
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作者：
H. Pan;B. Hoffman;R. Pershe;T. Blaschke
在多种实验动物中，由环磷酸腺苷介导的血管平滑肌β肾上腺素能松弛作用随着年龄的增长而减弱。这些观察结果对人类的适用性尚不确定。手背静脉技术提供了一种极好的方法来检查衰老对血管反应性的直接影响。对 39 名年龄在 19 岁至 79 岁之间的健康男性志愿者进行了研究。去氧肾上腺素（一种α肾上腺素能激动剂）的血管反应性在 ED50（产生 50% 血管收缩的剂量）或 Emax（达到的最大血管收缩）方面没有发现差异。与此形成鲜明对比的是，由异丙肾上腺素（一种 β 肾上腺素能激动剂）引起的血管舒张在 ED50（从预收缩状态产生最大舒张的 50% 的剂量）和 Emax（达到的最大舒张）方面均显着不同。 ED50 +/- S.E.M.最年轻和最年长的十分位数分别为 8.9 +/- 2.3 和 60 +/- 17.0 ng/min（P 小于 0.05）； Emax +/- S.E.M.分别为 96.7 +/- 3.3 和 37.7 +/- 8.7%（P 小于 0.001）。硝酸甘油是一种平滑肌松弛剂，其作用不通过环 AMP 系统介导，也被用来检查这种对异丙肾上腺素的钝化反应的特异性。老年组通过输注硝酸甘油实现了几乎完全的放松。这些结果表明衰老与β肾上腺素受体介导的血管舒张的特定减少有关。
Beta adrenergic relaxation of vascular smooth muscle, mediated by cyclic AMP, is blunted with age in a variety of experimental animals. The applicability of these observations to man is uncertain. The dorsal hand vein technique provides an excellent method to examine the direct effects of aging on vascular responsiveness. Thirty-nine healthy male volunteers over the age range of 19 to 79 were studied. No differences in vascular responsiveness to phenylephrine, an alpha adrenergic agonist, were found for either the ED50 (dose producing 50% vasoconstriction) or Emax (maximum vasoconstriction attained). In marked contrast, vascular relaxation induced by isoproterenol, a beta adrenergic agonist, was significantly different in both the ED50 (dose producing 50% of maximum relaxation from a preconstricted state) and Emax (maximum relaxation attained). ED50 +/- S.E.M. for the youngest and oldest deciles were 8.9 +/- 2.3 and 60 +/- 17.0 ng/min, respectively (P less than .05); Emax +/- S.E.M. were 96.7 +/- 3.3 and 37.7 +/- 8.7%, respectively (P less than .001). Nitroglycerin, a smooth muscle relaxant whose effects are not mediated through the cyclic AMP system, was also used to examine the specificity of this blunted response to isoproterenol. Almost complete relaxation was achieved with the infusion of nitroglycerin in the older group. These results suggest that aging is associated with a specific decrease in beta adrenoreceptor-mediated vascular relaxation.