Optothermal microbubble assisted manufacturing of nanogap-rich structures for active chemical sensing
Optothermal microbubble assisted manufacturing of nanogap-rich structures for active chemical sensing
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DOI：
10.1039/c9nr05892c
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发表时间：
2019-11-21
期刊：
影响因子：
6.7
通讯作者：
Zhao, Chenglong
中科院分区：
文献类型：
--
作者：
Karim, Farzia;Vasquez, Erick S.;Zhao, Chenglong
将分析物引导到传感区域是传感系统中不可缺少的步骤。大多数传感系统应用被动传感方法，其等待分析物向传感器扩散。然而，无源传感方法将分析物的检测限制在实际时间尺度上的微/纳米传感器上的皮摩尔范围内。因此，需要使用主动传感方法来提高检测限，其中分析物被迫集中在传感器上。在这篇文章中，我们展示了用于主动化学传感的纳米间隙丰富结构的制造。富纳米间隙结构是由金属纳米颗粒通过光热产生的微泡（OGMB），这是一个激光诱导的微米级气泡制造。OGMB诱导强对流，其有助于存款金属纳米颗粒以在固体表面上形成富含纳米间隙的结构。此外，OGMB用于引导和集中分析物朝向纳米间隙丰富的结构，用于分析物的主动感测。与被动传感方法相比，主动传感方法可以将化学物质的检测限提高一个数量级。微泡辅助制造的纳米间隙丰富的结构与主动分析物传感方法一起为先进的化学和生物传感应用铺平了新的道路。
Guiding analytes to the sensing area is an indispensable step in a sensing system. Most of the sensing systems apply a passive sensing method, which waits for the analytes to diffuse towards the sensor. However, passive sensing methods limit the detection of analytes to a picomolar range on micro/nanosensors for a practical time scale. Therefore, active sensing methods need to be used to improve the detection limit in which the analytes are forced to concentrate on the sensors. In this article, we have demonstrated the manufacturing of nanogap-rich structures for active chemical sensing. Nanogap-rich structures are manufactured from metallic nanoparticles through an optothermally generated microbubble (OGMB) which is a laser-induced micron-sized bubble. The OGMB induces a strong convective flow that helps to deposit metallic nanoparticles to form nanogap-rich structures on a solid surface. In addition, the OGMB is used to guide and concentrate analytes towards the nanogap-rich structures for the active sensing of analytes. An active sensing method can improve the detection limit of chemical substances by an order of magnitude compared to a passive sensing method. The microbubble assisted manufacturing of nanogap-rich structures together with an active analyte sensing method paves a new way for advanced chemical and bio-sensing applications.