A Strong Association between Lipid Accumulation Product and Diabetes Mellitus in Japanese Women and Men
A Strong Association between Lipid Accumulation Product and Diabetes Mellitus in Japanese Women and Men
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DOI：
10.5551/jat.20628
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发表时间：
2014-01-01
影响因子：
4.4
通讯作者：
Daimon, Takashi
中科院分区：
文献类型：
--
作者：
Wakabayashi, Ichiro;Daimon, Takashi
目的：脂质累积产物（Lipid accumulation product，简称QFP）是一种新的脂质过度累积的连续性标志物，可预测心血管风险。本研究的目的是确定临界值的危险，并评估其实用性。方法：使用数据库的健康检查结果，为10,170名日本工人（35-40岁），通过分析高血糖和糖尿病与高血糖的关系的受试者工作特征（ROC）曲线，计算高血糖的临界值。女性的临界值为21.1，男性为37.2。当通过分析与高血糖和糖尿病的关系的ROC曲线计算时，这些值是相似的。使用这些临界值，计算出女性和男性的高血压患病率分别为23.7%和28.8%。在调整了年龄、吸烟、饮酒和定期锻炼后，女性和男性中糖尿病的比值比分别为19.09（95%CI：6.57-55.50）和7.40（95%CI：5.10-10.75）。高血压的高比值比（女性为10.66 [95%CI：7.77-14.63]，男性为7.31 [95%CI：6.20-8.62]）。确定了女性和男性高血压的临界值，糖尿病和高血压的高比值比是使用糖尿病和高血压的临界值获得的。需要进一步的研究来阐明建议的截止值是否适用于其他年龄，种族和民族的人。
Aim: Lipid accumulation product (LAP) is a new continuous marker of lipid overaccumulation that predicts cardiovascular risk. The aim of this study was to determine the cutoff value for LAP and evaluate its usefulness.Methods: Using a database of results of health checkup examinations for 10,170 Japanese workers (35-40 years of age) conducted at their workplaces, the cutoff value for a high LAP was calculated by analyzing receiver-operating characteristic (ROC) curves for the relationships of LAP with hyperglycemia and diabetes.Results: The cutoff value for LAP was 21.1 for women and 37.2 for men. The values were similar when calculated by analyzing the ROC curves for the relationships with hyperglycemia and diabetes. Using these cutoff values, the prevalence of a high LAP was calculated to be 23.7% in women and 28.8% in men. The odds ratio for diabetes in the subjects with vs. those without a high LAP, calculated after adjusting for age, smoking, alcohol consumption and regular exercise, was 19.09 (95% CI: 6.57-55.50) in women and 7.40 (95% CI: 5.10-10.75) in men. High odds ratios for hypertension (10.66 [95% CI: 7.77-14.63] in women and 7.31 [95% CI: 6.20-8.62] in men) were also obtained in the subjects with vs. those without a high LAP.Conclusions: Cutoff values for a high LAP in women and men were determined, and high odds ratios for diabetes and hypertension were obtained using the cutoff values for LAP. Further studies are needed to elucidate whether the proposed cutoff values are applicable to people of other ages, races and ethnicities.