Pesticides and parkinsonism: is there an etiological link?
Pesticides and parkinsonism: is there an etiological link?
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DOI：
10.1097/00019052-200012000-00013
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发表时间：
2000-12
影响因子：
4.8
通讯作者：
A. Lockwood
中科院分区：
文献类型：
--
作者：
A. Lockwood
200年前，帕金森氏症很罕见。它是第二常见的神经退行性疾病。最近的一项双胞胎研究清楚地表明，遗传因素在决定一个人是否患上这种疾病方面起着次要作用，重新点燃了人们对环境因素的病因学意义的兴趣。早期的研究表明，MPTP，一种在一些非法药物中发现的污染物，导致帕金森病。这为杀虫剂假说提供了最初的动力。MPTP和农药之间的相似性，加上流行病学和动物研究，加强了农药暴露和帕金森病的后续发展之间的可能联系。
Two hundred years ago, Parkinson's disease was rare. Now, it is the second most common neurodegenerative disorder. A recent twin study showed clearly that genetic factors play a minor role in determining whether an individual develops this disease, rekindling an interest in the etiological significance of environmental factors. Earlier studies had shown that a MPTP, a contaminant found in some illegal drugs, caused Parkinson's disease. This provided the original impetus for the pesticide hypothesis. Similarities between MPTP and pesticides coupled with epidemiological and animal studies have strengthened the possible link between pesticide exposure and the subsequent development of Parkinson's disease.