Reduction in Drinking was Associated With Improved Clinical Outcomes in Women With HIV Infection and Unhealthy Alcohol Use: Results From a Randomized Clinical Trial of Oral Naltrexone Versus Placebo
Reduction in Drinking was Associated With Improved Clinical Outcomes in Women With HIV Infection and Unhealthy Alcohol Use: Results From a Randomized Clinical Trial of Oral Naltrexone Versus Placebo
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DOI：
10.1111/acer.14130
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发表时间：
2019-08-01
影响因子：
3.2
通讯作者：
Bryant, Kendall
中科院分区：
文献类型：
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作者：
Cook, Robert L.;Zhou, Zhi;Bryant, Kendall
饮酒与感染艾滋病毒的妇女（WLWH）健康状况不佳有关，但目前尚不清楚药物是否有助于减少未寻求治疗的妇女的饮酒，或者减少饮酒是否能改善艾滋病毒预后。我们对符合当前不健康饮酒标准的WLWH患者进行了每日口服纳曲酮（50 mg）与安慰剂的随机临床试验（RCT）。方法目前有不健康饮酒习惯（每周饮酒7次或3次）的产妇随机分为每日口服纳曲酮50 mg组（n = 96）或安慰剂组（n = 98），为期4个月。饮酒后果，包括女性减少饮酒的比例(
Background Alcohol consumption is associated with poor health outcomes in women living with HIV (WLWH), but whether medication can help to reduce drinking in non-treatment-seeking women or whether reduction in drinking improves HIV outcomes is unclear. We conducted a randomized clinical trial (RCT) of daily oral naltrexone (50 mg) versus placebo in WLWH who met criteria for current unhealthy alcohol use. Methods WLWH with current unhealthy alcohol use (>7 drinks/wk or >3 drinks/occasion) were randomly assigned to daily oral naltrexone 50 mg (n = 96) or placebo (n = 98) for 4 months. Drinking outcomes, including the proportion of women who reduced (