The transmission disequilibrium test suggests that HLA-DR4 and DR13 are linked to autism spectrum disorder
The transmission disequilibrium test suggests that HLA-DR4 and DR13 are linked to autism spectrum disorder
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DOI：
10.1016/s0198-8859(02)00374-9
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发表时间：
2002-04-01
期刊：
影响因子：
2.7
通讯作者：
Odell, D
中科院分区：
文献类型：
--
作者：
Torres, AR;Maciulis, A;Odell, D
我们评估了103个高加索血统的自闭症谱系障碍（ASD）的HLA-DRB 1等位基因的可能贡献。DR 4等位基因在先证者中的出现频率高于对照组（0.007），而DR 13，14等位基因在先证者中的出现频率低于对照组（P = 0.003）。传递不平衡检验（TDT）显示，ASD先证者从父亲遗传DR 4等位基因的频率高于预期（p = 0.026）。TDT还显示ASD先证者从母亲遗传DR 13等位基因的频率低于预期（p = 0.006）。我们的结论是，TDT结果表明DR 4和DR 13与ASD有关。父母遗传特定等位基因的原因知之甚少，但与目前的遗传研究一致，注意到自闭症中可能的父母起源效应。(C)美国组织相容性和免疫遗传学学会，2002年。出版社：Elsevier Science Inc.
We have evaluated possible contributions of HLA-DRB1 alleles to autism spectrum disorder (ASD) in 103 families of Caucasian descent. The DR4 allele occurred more often in probands than controls (0.007), whereas the DR13,14 alleles occurred less often in probands than controls (P = 0.003). The transmission disequilibrium test (TDT) indicated that the ASD probands inherited the DR4 allele more frequently than expected (p = 0.026) from the fathers, The TDT also revealed that fewer DR 13 alleles than expected were inherited from the mother by ASD probands (p = 0.006). We conclude that the TDT results suggest that DR4 and DR13 are linked to ASD. Reasons for the parental inheritance of specific alleles are poorly understood but coincide with current genetic research noting possible parent-of-origin effects in autism. (C) American Society for Histocompatibility and Immunogenetics, 2002. Published by Elsevier Science Inc.