Association between mismatch negativity and global functioning is specific to duration deviance in early stages of psychosis
Association between mismatch negativity and global functioning is specific to duration deviance in early stages of psychosis
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DOI：
10.1016/j.schres.2017.09.045
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发表时间：
2018-05-01
影响因子：
4.5
通讯作者：
Kasai, Kiyoto
中科院分区：
文献类型：
--
作者：
Koshiyama, Daisuke;Kirihara, Kenji;Kasai, Kiyoto
背景：错配负波（MMN）是精神病早期阶段的候选生物标志物。虽然持续时间MMN（dMMN），认知功能障碍，慢性精神分裂症的功能结果之间的关联已被证明由一个大规模的研究，偏差类型和临床stages的影响还没有investigated.Methods：我们调查了dMMN，频率MMN（fMMN），全球功能，和认知功能之间的关系在精神病的早期阶段。参与者包括26名新近发作的精神分裂症（ROSZ）患者，30名超高风险（UHR）患者和20名健康对照者。相关性分析显示，与健康对照组相比，ROSZ组的dMMN振幅受损，与ROSZ（r = -0.45）和UHR（r = -0.37）组的总体功能（功能-功能量表的总体评估）相关。各组之间的fMMN振幅没有差异，仅在ROSZ组中与工作记忆相关（r = -0.57）。路径分析表明，dMMN有一个直接的影响，在ROSZ和UHR组的全球功能，而fMMN有一个直接的影响，工作记忆只有在ROSZ group.Conclusions：我们的研究结果表明，MMN和全球功能之间的关联是特定的持续时间偏差，并已经存在于精神病的早期阶段。这些发现证实了dMMN作为早期精神病的生物标志物指导治疗干预的有用性。(C)2017爱思唯尔B. V.保留所有权利。
Background: Mismatch negativity (MMN) is a candidate biomarker for early stages of psychosis. Although an association among duration MMN (dMMN), cognitive deficits, and functional outcome in chronic schizophrenia has been shown by a large-scale study, the effects of deviant type and clinical stages have not been investigated.Methods: We investigated the relationships among dMMN, frequency MMN (fMMN), global functioning, and cognitive function in early stages of psychosis. The participants included 26 individuals with recent-onset schizophrenia (ROSZ), 30 individuals with ultra-high risk (UHR), and 20 healthy controls.Results: The correlational analyses revealed that dMMN amplitude, which was impaired in the ROSZ group compared to the healthy controls, correlated with global functioning (Global Assessment of Functioning-Functioning scale) in the ROSZ (r = -0.45) and UHR (r = -0.37) groups. The amplitude of fMMN, which did not differ among the groups, correlated with working memory (r = -0.57) only in the ROSZ group. The path analyses indicated that dMMN had a direct effect on global functioning in the ROSZ and UHR groups while fMMN had a direct effect on working memory only in the ROSZ group.Conclusions: Our findings suggested that the association between MMN and global functioning was specific to the duration deviant and was already present in early stages of psychosis. These findings confirm the usefulness of dMMN as a biological marker of early psychosis to guide treatment interventions. (C) 2017 Elsevier B.V. All rights reserved.