[Efficacy of the "8 drugs in a day" protocol in brain tumors in children].
[Efficacy of the "8 drugs in a day" protocol in brain tumors in children].
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“一日八药”方案治疗儿童脑肿瘤的疗效[J].
DOI：
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
M. Brunat
中科院分区：
文献类型：
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作者：
P. Chastagner;D. Olive;T. Philip;J. Zucker;A. Czorny;C. Lapras;M. Brunat
在本研究中，在54名儿童中测试了“1天8种药物”方案：27例复发（脑和/或脊髓和/或脑膜部位），10例难治性进展性疾病，13例部分切除和/或放疗后肉眼可见的残留肿瘤;在4例病例中，该方案被规定为一线治疗。有效率（完全和部分缓解）为46%。结果是非常令人鼓舞的髓母细胞瘤的反应率为76.5%，而在脑干胶质瘤，它只有23%和33%的其他星形细胞瘤。即刻毒性（主要是血液学毒性）非常中度。这些结果证明，建议这种方案作为辅助化疗，主要是在髓母细胞瘤和计划其他类似的试验，使用最活跃的药物，目前似乎是烷基化和铂衍生剂。
In the present study, the "8 drugs in 1 day" regimen was tested in 54 children: 27 relapses (brain and/or spinal and/or meningeal sites), 10 refractory progressive diseases, 13 macroscopic residual tumors after partial excision and/or radiotherapy; in 4 cases, this regimen was prescribed as first line treatment. The response rate (complete and partial remission) was 46%. Results were very encouraging in medalloblastomas with a response rate of 76.5% whereas in brain stem gliomas it was only 23% and 33% in other astrocytomas. Immediate toxicity, mainly hematological, was very moderate. These results justify to propose this regimen as adjuvant chemotherapy, mostly in medulloblastomas and to plan other similar trials, using the most active drugs which seem presently to be alkylating and platinum-derived agents.