DIFFERENTIAL ACTIVATION OF THE 5-HYDROXYTRYPTAMINE-CONTAINING NEURONS OF THE MIDBRAIN RAPHE OF THE RAT IN RESPONSE TO RANDOMLY PRESENTED INESCAPABLE SOUND
DIFFERENTIAL ACTIVATION OF THE 5-HYDROXYTRYPTAMINE-CONTAINING NEURONS OF THE MIDBRAIN RAPHE OF THE RAT IN RESPONSE TO RANDOMLY PRESENTED INESCAPABLE SOUND
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DOI：
10.1016/0304-3940(95)12027-2
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发表时间：
1995-10-13
影响因子：
2.5
通讯作者：
BOADLEBIBER, MC
中科院分区：
文献类型：
--
作者：
DILTS, RP;BOADLEBIBER, MC
通过给予芳香族氨基酸脱羧酶抑制剂（腹腔注射 100 mg/kg，间羟基苯甲基肼，NSD）后 5-羟色氨酸（5-HTP）的积累，获得了大鼠大脑中含有 5-HT 周核的区域对 30 分钟不可避免的、随机出现的响亮声音（声音应激）的 5-羟色胺（5-HT）周转率的估计。 1015）。声音应激使中缝核（MRN）中的 5-HTP 积累量比假应激对照增加两倍，但并未显着改变中缝核（DRN）或后脑中的 5-HTP 积累。这些发现表明，MRN 的 5-HT 核周体被声音应激激活，而 DRN 或后脑的 5-HT 核周体则不然，因此，为这两个神经元的 5-HT 神经元之间的功能区别提供了进一步的证据。中脑核团。
Estimates of 5-hydroxytryptamine (5-HT) turnover in response to 30 min of inescapable, randomly presented, loud sound (sound stress) were obtained for regions of rat brain containing 5-HT perikarya by means of 5-hydroxytryptophan (5-HTP) accumulation after administration of an inhibitor of aromatic amino acid decarboxylase (100 mg/kg i.p., m-hydroxybenzylhydrazine, NSD 1015). Sound stress increased 5-HTP accumulation in the median raphe nucleus (MRN) twofold over that from sham-stressed controls, but did not change 5-HTP accumulation significantly in dorsal raphe nucleus (DRN) or hindbrain, These findings indicate that the 5-HT perikarya of the MRN but not those of the DRN or hindbrain are activated by sound stress, and thus, provide further evidence for a functional distinction between the 5-HT neurons of these two midbrain nuclei.