MELATONIN-INDUCED TEMPERATURE SUPPRESSION AND ITS ACUTE PHASE-SHIFTING EFFECTS CORRELATE IN A DOSE-DEPENDENT MANNER IN HUMANS
MELATONIN-INDUCED TEMPERATURE SUPPRESSION AND ITS ACUTE PHASE-SHIFTING EFFECTS CORRELATE IN A DOSE-DEPENDENT MANNER IN HUMANS
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DOI：
10.1016/0006-8993(95)96872-i
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发表时间：
1995-08-07
期刊：
影响因子：
2.9
通讯作者：
ARENDT, J
中科院分区：
文献类型：
--
作者：
DEACON, S;ARENDT, J
褪黑激素能够使内源性生物钟发生相移，并可诱导急性温度抑制。这些现象之间可能有直接的关系。在一项双盲、安慰剂对照的交叉研究中，6名健康志愿者在正常环境中保持规律的睡眠/觉醒周期。在第1-4天，从黄昏到24：00 h，受试者从24：00-08：00 h保持在昏暗的人工照明（< 50 lux）和黑暗（< 1 lux）中。在D3的17：00 h，给予褪黑激素（0.05 mg、0.5 mg或5 mg）或安慰剂。褪黑激素治疗可诱导急性、剂量依赖性的体温抑制以及警觉性和表现效率的下降。在D3的晚上，更早的睡眠开始、偏移和更好的睡眠质量与褪黑激素剂量的增加相关。第二天，观察到血浆褪黑激素起效时间和温度最低点（D4-5）的显著剂量依赖性相位提前，警觉性节律有相位提前的趋势。一个显着的剂量-反应关系之间存在的剂量的口服褪黑激素，温度抑制的幅度和程度的提前相移的内源性褪黑激素和温度节律，表明褪黑激素在体温的急性变化可能是一个主要事件的相移机制。
Melatonin is able to phase-shift the endogenous circadian clock and can induce acute temperature suppression. It is possible that there is a direct relationship between these phenomena. In a double-blind, placebo-controlled crossover study, 6 healthy volunteers maintained a regular sleep/wake cycle in a normal environment. From dusk until 24:00 h on days (D) 1-4 subjects remained in dim artificial lighting(< 50 lux) and darkness(< 1 lux) from 24:00-08:00 h. At 17:00 h on D3 either melatonin (0.05 mg, 0.5 mg or 5 mg) or placebo was administered. Melatonin treatment induced acute, dose-dependent temperature suppression and decrements in alertness and performance efficiency. On the night of D3, earlier sleep onset, offset and better sleep quality were associated with increasing doses of melatonin. The following day, a significant dose-dependent phase-advance in the plasma melatonin onset time and temperature nadir (D4-5) was observed with a trend for the alertness rhythm to phase-advance. A significant dose-response relationship existed between the dose of oral melatonin, the magnitude of temperature suppression and the degree of advance phase shift in the endogenous melatonin and temperature rhythms, suggesting that acute changes in body temperature by melatonin may be a primary event in phase-shifting mechanisms.