Autoantibodies in celiac disease
Autoantibodies in celiac disease
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DOI：
10.1080/08916930701619219
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发表时间：
2008-01-01
期刊：
影响因子：
3.5
通讯作者：
Green, Peter H. R.
中科院分区：
文献类型：
--
作者：
Alaedini, Armin;Green, Peter H. R.
自身抗体的产生是许多自身免疫性疾病的一个重要特征，标志着对自身抗原的免疫耐受性的崩溃。在乳糜泻中，一种具有多种肠外表现的自身免疫性肠病，对转谷氨酰胺酶 2 (TG2) 的自身抗体反应性已被证明与该疾病的急性期密切相关。它是乳糜泻的特异性和敏感标志物，对于帮助诊断和随访非常有用。在乳糜泻中也有报道称，对其他自身抗原（包括转谷氨酰胺酶 3、肌动蛋白、神经节苷脂、胶原蛋白、钙网蛋白和连蛋白等）的免疫反应性。这些抗体的临床意义尚不清楚，尽管有些可能与乳糜泻的特定临床表现或肠外表现有关。这篇综述检查了乳糜泻中抗 TG2 和其他自身抗体的存在，讨论了它们的诊断价值、它们在疾病发病机制中的潜在作用以及解释它们如何释放的当前假设。
Autoantibody production is an important feature of many autoimmune disorders, signifying a breakdown of immune tolerance to self-antigens. In celiac disease, an autoimmune enteropathy with multiple extra-intestinal manifestations, autoantibody reactivity to transglutaminase 2 (TG2) has been shown to closely correlate with the acute phase of the disease. It serves as a specific and sensitive marker of celiac disease, and is highly useful in aiding diagnosis and follow-up. Immune reactivity to other autoantigens, including transglutaminase 3, actin, ganglioside, collagen, calreticulin and zonulin, among others, has also been reported in celiac disease. The clinical significance of these antibodies is not known, although some may be associated with specific clinical presentations or extra-intestinal manifestations of celiac disease. This review examines the presence of anti-TG2 and other autoantibodies in celiac disease, discussing their diagnostic value, their potential role in disease pathogenesis and current hypotheses that explain how their release may be triggered.