Synthesis, spectral and cytotoxicity studies of palladium(II) and platinum(II) amino acid Schiff base complexes
Synthesis, spectral and cytotoxicity studies of palladium(II) and platinum(II) amino acid Schiff base complexes
复制标题
DOI：
10.1023/a:1007055304150
复制
发表时间：
2000-01-01
影响因子：
1.7
通讯作者：
Martelli, S
中科院分区：
文献类型：
--
作者：
Offiong, OE;Nfor, E;Martelli, S
合成了取代邻羟基苯乙酮-甘氨酸的新型Pd-II和Pt-II配合物，并用电导、红外光谱、电子光谱和H-1-n.m.r对其进行了表征。光谱。光谱数据表明，配体是一元双齿配位的，通过亚氨基氮和羧酸基配位。所有的络合物都被提出了一个四坐标方平面构型。这些配体及其Pd-II和Pt-II络合物在体外对艾氏腹水癌细胞显示出强大的细胞毒活性，但在体内似乎更具活性。
Novel Pd-II and Pt-II complexes of substituted o-hydroxyacetophenone-glycine have been synthesized, and characterized by conductivity measurements, i.r., electronic and H-1-n.m.r. spectra. The spectral data indicate that the ligands are monobasic bidentate, coordinating through imino nitrogen and the carboxylate group. A four coordinate square planar configuration has been proposed for all the complexes. The ligands, as well as their Pd-II and Pt-II complexes, exhibit potent cytotoxic activity against Ehrlich ascites tumour cells in vitro, but appear to be more active in vivo.