Secondary chronic myelogenous leukemia after chemotherapy followed by adjuvant radiotherapy for small cell lung cancer
Secondary chronic myelogenous leukemia after chemotherapy followed by adjuvant radiotherapy for small cell lung cancer
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DOI：
10.1016/s0145-2126(99)00114-9
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发表时间：
1999-10-01
影响因子：
2.7
通讯作者：
Lange, W
中科院分区：
文献类型：
--
作者：
Waller, CF;Fetscher, S;Lange, W
一例40岁的小细胞肺癌（SCLC）患者接受大剂量化疗+自体外周血祖细胞移植+辅助放疗的联合治疗。他的原发疾病完全缓解了。间隔28个月后，他被诊断为慢性粒细胞白血病（CML）。用聚合酶链反应（PCR）对SCLC初次治疗时的移植物样本进行分析，没有显示出CML的bcr-abl转录物特征。本病例支持CML可以发展为治疗相关的恶性肿瘤的观察，并在疾病的临床前阶段的长度提供了见解。1999爱思唯尔科学有限公司版权所有。
A 40-year old patient with small cell lung cancer (SCLC) was treated with combined modalities including high-dose chemotherapy with subsequent autologous peripheral blood progenitor cell transplantation plus adjuvant radiotherapy. He achieved complete remission with regards to the primary disease. After an interval of 28 months, he was diagnosed with chronic myelogenous leukemia (CML). Analysis of graft samples at time of primary treatment for SCLC using polymerase chain reaction (PCR) did not show the bcr-abl transcript characteristic for CML. This case supports the observation that CML can develop as a treatment-related malignancy and gives insight in the length of the preclinical phase of the disease. (C) 1999 Elsevier Science Ltd. All rights reserved.