Measuring the impact of Parkinson's disease with the Parkinson's disease quality of life questionnaire
Measuring the impact of Parkinson's disease with the Parkinson's disease quality of life questionnaire
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DOI：
10.1093/ageing/28.4.341
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发表时间：
1999-07-01
期刊：
影响因子：
6.7
通讯作者：
Meara, J
中科院分区：
文献类型：
--
作者：
Hobson, P;Holden, A;Meara, J
目的：使用疾病严重程度、抑郁症状和认知功能的标准化测量方法，评估帕金森病患者生活质量问卷(PDQL)在社区帕金森病患者样本中的效度。设计：从社区登记的194名可能的帕金森病患者中随机抽取194名患者，邀请他们自行完成37个条目的PDQL。用疾病特异性韦氏评定量表评定疾病严重程度，用CAMCOG神经心理测验评定认知能力，用15个条目的GDS-15老年抑郁量表评定抑郁症状。在根据疾病严重程度分组的患者的综合PDQL评分之间出现显著差异(P<；0.05)。抑郁症状和认知也与PDQL测量的较差的生活质量相关。结论：本研究结果表明，PDQL作为从患者角度反映帕金森病影响的重要附加测量工具是有效的。它表明，较差的生活质量与年龄增长、疾病严重程度、更严重的抑郁症状和认知功能受损有关。然而，这一工具在评估帕金森病患者护理方面的响应性仍有待确定。
Objectives: to assess the validity of the Parkinson's Disease Quality of Life (PDQL) questionnaire, a patient-specific multi-dimensional quality of life measure, in a community-based sample of patients with Parkinson's disease (PD) using standardized measures of disease severity, depressive symptomatology and cognitive function.Design: a group of 194 patients with probable PD were randomly selected from a community-based register and were invited to self-complete the 37-item PDQL. Disease severity was measured by the disease-specific Webster scale, cognition by the CAMCOG neuropsychological test and depressive symptomatology by the self-report 15-item GDS-15 geriatric depression scale.Results: a total of 136 patients returned completed PDQL questionnaires. Significant differences (P < 0.05) emerged between the pooled PDQL score of patients grouped on the basis of disease severity. Depressive symptoms and cognition were also associated with poorer perceived quality of life as measured by the PDQL.Conclusions: the results of this study are indicative of the validity of the PDQL as an important additional measurement which reflects the impact of PD from the patient perspective. It shows poorer quality of life to be associated with increasing age, disease severity, more severe depressive symptomatology and impaired cognitive functioning. However, the responsiveness of this instrument in the evaluation of care in PD remains to be determined.