MOLECULAR-CLONING ESTABLISHES PRO-ENKEPHALIN AS PRECURSOR OF ENKEPHALIN-CONTAINING PEPTIDES
MOLECULAR-CLONING ESTABLISHES PRO-ENKEPHALIN AS PRECURSOR OF ENKEPHALIN-CONTAINING PEPTIDES
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DOI：
10.1038/295206a0
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发表时间：
1982-01-01
期刊：
影响因子：
64.8
通讯作者：
UDENFRIEND, S
中科院分区：
文献类型：
--
作者：
GUBLER, U;SEEBURG, P;UDENFRIEND, S
分子克隆和DNA测序已经获得了大量关于前脑啡肽原的结构信息。所有先前表征的牛肾上腺髓质脑啡肽途径的中间肽现在已经排列成明确的一级结构。两个碱性氨基酸残基用作释放每种不同组分的加工信号。
Molecular cloning and DNA sequencing have yielded considerable structural information about proenkephalin. All previously characterized intermediate peptides of the enkephalin pathway in bovine adrenal medulla have now been aligned into an unambiguous primary structure. Two basic amino acid residues serve as processing signals for release of each of the different components.