Synaptic plasticity (and the lack thereof) in hippocampal CA2 neurons
Synaptic plasticity (and the lack thereof) in hippocampal CA2 neurons
复制标题
DOI：
10.1523/jneurosci.4094-07.2007
复制
发表时间：
2007-10-31
影响因子：
5.3
通讯作者：
Dudek, Serena M.
中科院分区：
文献类型：
--
作者：
Zhao, Meilan;Choi, Yun-Sik;Dudek, Serena M.
海马体对于某些形式的记忆和空间导航至关重要，但以前的研究大多忽略了CA2，这是位于CA3和CA1之间的独特区域。在这里，我们表明，CA2锥体神经元具有独特的生理特征，包括前所未有的突触稳定性。虽然CA1和CA2的基础突触电流非常相似，但包括长时程增强和长时程抑制在内的突触可塑性不存在或不太可能用CA2中的常规刺激方法诱导。我们还发现，CA 2神经元有更大的泄漏电流和更多的负静息膜电位比CA 1神经元，因此，更多的电流是需要在CA 2神经元的动作电位产生。这些数据表明，CA2中的分子“对抗可塑性的阴谋”使其在功能上不同于其他海马CA区域。这项工作提供了关键的洞察海马功能，并可能导致对CA2抵抗疾病，创伤和缺氧损伤的理解。
The hippocampus is critical for some forms of memory and spatial navigation, but previous research has mostly neglected the CA2, a unique region situated between CA3 and CA1. Here, we show that CA2 pyramidal neurons have distinctive physiological characteristics that include an unprecedented synaptic stability. Although basal synaptic currents in CA1 and CA2 are quite similar, synaptic plasticity including long-term potentiation and long-term depression is absent or less likely to be induced with conventional methods of stimulation in CA2. We also find that CA2 neurons have larger leak currents and more negative resting membrane potentials than CA1 neurons, and consequently, more current is required for action potential generation in CA2 neurons. These data suggest that the molecular "conspiracy against plasticity" in CA2 makes it functionally distinct from the other hippocampal CA regions. This work provides critical insight into hippocampal function and may lead to an understanding of the resistance of CA2 to damage from disease, trauma, and hypoxia.