An improved system for the palladium-catalyzed borylation of aryl halides with pinacol borane
An improved system for the palladium-catalyzed borylation of aryl halides with pinacol borane
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DOI：
10.1021/jo800727s
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发表时间：
2008-07-18
影响因子：
3.6
通讯作者：
Buchwald, Stephen L.
中科院分区：
文献类型：
--
作者：
Billingsley, Kelvin L.;Buchwald, Stephen L.
研究了一种廉价、原子经济的硼源品萘醇硼烷对芳基卤化物的硼化反应。该系统允许将含有各种官能团的芳基和杂芳基碘化物、溴化物和几种氯化物转化为相应的品纳科尔硼酸酯。除了增加底物范围外，这是第一种可以使用相对少量催化剂和较短反应时间的通用方法。
borylation of aryl halides with an inexpensive and atom-economical boron source, pinacol borane, has been developed. This system allows for the conversion of aryl and heteroaryl iodides, bromides, and several chlorides, containing a variety of functional groups, to the corresponding pinacol boronate esters. In addition to the increase in substrate scope, this is the first general method where relatively low quantities of catalyst and short reaction times can be employed.