Facilitation of conditioned taste aversion learning by systemic amphetamine:: role of nucleus accumbens shell dopamine D1 receptors
Facilitation of conditioned taste aversion learning by systemic amphetamine:: role of nucleus accumbens shell dopamine D1 receptors
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DOI：
10.1046/j.1460-9568.2003.02899.x
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发表时间：
2003-10-01
影响因子：
3.4
通讯作者：
Di Chiara, G
中科院分区：
文献类型：
--
作者：
Fenu, S;Di Chiara, G
以蔗糖为条件刺激（CS），氯化锂为非条件刺激（US），在条件性味觉厌恶（CTA）实验中研究多巴胺（DA）在联想学习中的作用。在试验中饮用15%蔗糖溶液，1小时后饮用氯化锂（20或40 mg/kg i. p.）导致轻度CTA，如24小时后饮用蔗糖溶液减少所示。硫酸安非他明（0.125、0.25、0.50和1.0 mg/kg s.c.），在试验中，在饮用蔗糖后5分钟给予0.25 mg/kg s.c.安非他明给予在没有锂或45分钟后，蔗糖没有影响蔗糖的摄入量。DA D-1受体拮抗剂SCH 39166在苯丙胺之前全身给药（0.0125 mg/kg s.c.）或在丘脑核壳（NAc;每侧0.025 μ g/穆尔）中的抑制剂阻止了苯丙胺诱导的CTA的易化。结论：苯丙胺通过NAc壳的D-1受体加强味觉短期记忆的巩固，促进CTA学习。
The role of dopamine (DA) in associative learning was studied in a conditioned taste aversion (CTA) paradigm with sucrose as the conditioned stimulus (CS) and intraperitoneal lithium chloride as the unconditioned stimulus (US). Drinking on trial of a 15% sucrose solution followed 1 h later by lithium chloride (20 or 40 mg/kg i.p.) resulted in mild CTA, as shown by reduction of drinking of the sucrose solution 24 h later. Amphetamine sulphate (0.125, 0.25, 0.50 and 1.0 mg/kg s.c.), administered on trial 5 min after sucrose drinking, facilitated CTA with maximal effects at 0.25 mg/kg s.c. Amphetamine given in the absence of lithium or 45 min after sucrose did not affect sucrose intake. The DA D-1 receptor antagonist SCH 39166, administered before amphetamine either systemically (0.0125 mg/kg s.c.) or in the nucleus accumbens shell (NAc; 0.025 mug/muL on each side) prevented the facilitation of CTA induced by amphetamine. It is concluded that amphetamine facilitates CTA learning by strengthening the consolidation of gustatory short-term memory via D-1 receptors of the NAc shell.