STUDIES OF INTERRELATIONSHIP BETWEEN CEREBROSPINAL-FLUID AND PLASMA AMINO-ACID CONCENTRATIONS IN NORMAL INDIVIDUALS
STUDIES OF INTERRELATIONSHIP BETWEEN CEREBROSPINAL-FLUID AND PLASMA AMINO-ACID CONCENTRATIONS IN NORMAL INDIVIDUALS
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DOI：
10.1111/j.1471-4159.1977.tb09621.x
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发表时间：
1977-01-01
影响因子：
4.7
通讯作者：
ABER, GM
中科院分区：
文献类型：
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作者：
MCGALE, EHF;PYE, IF;ABER, GM
测定了37例空腹正常受试者腰SCF中游离氨基酸的浓度。将这些数值与同时采集的静脉血浆中相同氨基酸的浓度和脑脊液中氨基酸的浓度进行比较。在脑脊液和血浆中鉴定和定量了23种氨基酸。微量的其他8种氨基酸也被检测到。脑脊液中13种氨基酸的浓度与血药浓度直接相关。其他7种氨基酸则没有这种关系。个体氨基酸浓度的显著变化与年龄和性别有关。脑脊液中发现大量不明的茚三酮阳性化合物。初步研究已经确定其中一种是GABA。
The concentration of free amino acids was determined in lumbar SCF in 37 fasting normal subjects. The values were compared with the concentration of the same amino acids measured in venous plasma collected simultaneously and with ventricular CSF amino acid concentrations. Twenty-three amino acids were identified and quantitated in CSF and plasma. Trace quantities of 8 other amino acids were also detected. The concentration of 13 amino acids in CSF was directly related to the plasma concentration. No such relationship was noted for the other 7 amino acids. Significant variations in the concentration of individual amino acids relating to both age and sex were noted. A large number of unidentified ninhydrin positive compounds were found in CSF. Preliminary studies have identified one of these as GABA.