Absence of 'over-the-counter' medicinal products in on-line prescription records: a risk factor of overlooking interactions in the elderly
Absence of 'over-the-counter' medicinal products in on-line prescription records: a risk factor of overlooking interactions in the elderly
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DOI：
10.1002/pds.3362
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发表时间：
2013-02-01
影响因子：
2.6
通讯作者：
Damsgaard, E. M.
中科院分区：
文献类型：
--
作者：
Olesen, C.;Harbig, P.;Damsgaard, E. M.
目的：评估丹麦在线处方记录中目前缺乏非处方（OTC）药物信息所引起的老年患者有害相互作用的可能来源。方法通过家庭访问访谈收集处方药和OTC药品（非处方药、草药、膳食补充剂等）的当前使用信息。后一种非处方药没有列入过去两年的网上处方记录。从丹麦国家药物相互作用数据库中获得OTC药物之间以及OTC产品与处方药之间相互作用的信息。结果在309例患者中（中位年龄75岁，四分位距（IQR）7081），229例（74%）使用了568种未在丹麦在线处方记录中列出的OTC药物，其中我们确定了166种潜在的相互作用-OTC治疗之间或OTC与处方药之间。服用OTC药物的患者中有50%暴露于潜在的相互作用，即每位患者1 - 3例。暴露于相互作用的患者中有25%经历了列为“可与某些ψ作用一起使用”的相互作用。结论：在线处方记录中OTC产品信息的缺失可能导致忽视老年患者相互作用的风险。此类产品应包括在在线用药记录中，以防止相互作用产生不良影响。然而，并非所有国家都有在线用药记录，而且目前纳入非处方药数据似乎不可行。尽管如此，强烈建议定期审查患者的药物清单。版权所有（c）2012约翰威利父子有限公司
Purpose To assess possible origins of harmful interactions in elderly patients arising from the current absence of information on over-the-counter (OTC) medicines in the Danish on-line prescription record'. Methods Information on current use of prescription drugs and OTC medicinal products (non-prescription drugs, herbal medicine, dietary supplements, and others) was collected by home visit interviews. The latter OTC products were not listed in an on-line prescription record that covered the previous two years. Information on interactions between OTC medicines and between OTC products and prescription drugs was obtained from the Danish National Drug Interaction Database. Results Of the 309 patients recruited (median age 75years, interquartile range (IQR) 7081), 229 (74%) used 568 OTC medicines not listed in the Danish on-line prescription record', amongst which we identified 166 potential interactions - between OTC treatments or between OTC and prescription drugs. Fifty percent of patients taking OTC medicines were exposed to potential interactions, i.e. one to three instances per patient. Twenty-five percent of patients exposed to interactions experienced interaction listed as Can be used with certain precautions'. Conclusion The absence of information on OTC products in an on-line prescription record entails a risk of overlooking interactions in elderly patients. Such products should be included in on-line medication records to prevent adverse effects from interactions. However, online medication records are not available in all countries and as inclusion of data on OTC drugs seem not to be feasible presently. Still, it is highly recommended that the patient's drug list is reviewed on a regular basis. Copyright (c) 2012 John Wiley & Sons, Ltd.