EXPERIMENTAL-EVIDENCE OF ISCHEMIC THRESHOLDS AND FUNCTIONAL RECOVERY
EXPERIMENTAL-EVIDENCE OF ISCHEMIC THRESHOLDS AND FUNCTIONAL RECOVERY
复制标题
DOI：
10.1161/01.str.23.11.1668
复制
发表时间：
1992-11-01
期刊：
影响因子：
8.3
通讯作者：
HEISS, WD
中科院分区：
文献类型：
--
作者：
HEISS, WD
背景：某些临界水平以下的血流受损和富含能量的底物的供应不足会导致神经元功能衰竭，触发生化紊乱，最终导致缺血细胞损伤。综述：本文综述了试图使用功能和组织学标志物以及最近的缺血损伤的化学标志物来确定这些缺血阈值的实验研究。结论：造成不可逆细胞损伤的缺血持续时间仍不明确。在短暂性脑缺血发作后，必须尽早恢复充分的血流灌注，以减轻潜在的有害生化后遗症。
Background: Impaired blood flow below certain critical levels and an insufficient supply of energy-rich substrates cause failure of neuronal function, triggering biochemical disturbances that eventually lead to ischemic cell damage.Summary of Review: This article reviews experimental studies that attempted to define those ischemic thresholds using functional and histological markers and, more recently, chemical markers of ischemic damage.Conclusions: The duration of ischemia causing irreversible cell damage still is ill defined. Reestablishment of sufficient perfusion must be induced very early after an ischemic attack to ameliorate the potentially harmful biochemical sequelae of transient ischemia.