May be adenosine an immuno-quorum-sensing signal?
May be adenosine an immuno-quorum-sensing signal?
复制标题
DOI：
10.1007/s11302-022-09866-2
复制
发表时间：
2022-04-30
影响因子：
3.5
通讯作者：
Hasko，Gyorgy
中科院分区：
文献类型：
--
作者：
Antonioli，Luca;Hasko，Gyorgy
群体感应是指细菌之间基于基因表达的协调变化而进行的一种交流过程，旨在协调与细菌种群密度相关的集体行为。越来越多的证据指出，群体感应系统可以是一种调节程序，也可以用于免疫领域，以组织各种免疫细胞群体的密度，并校准它们的反应。特别是，这种平衡是通过免疫细胞感知自身或环境中其他细胞的密度的能力实现的，通过释放几种能够通过基因表达和蛋白质信号的协调变化来精细塑造细胞密度的介质。在这一点上，腺苷表现出参与群体感应调节的媒介的典型特征，因此表明这种核苷在塑造不同免疫细胞群体之间的平衡方面发挥了假定的作用。
Quorum sensing indicates a communication process between bacteria based on a coordinate variation in gene expression aimed at coordinating a collective comportment related to the bacterial population density. Increasing pieces of evidence pointed out that a quorum-sensing system can be a regulatory program also used in the immune field to organize the density of the various immune cell populations and to calibrate their responses. In particular, such equilibrium is achieved by the ability of immune cells to perceive the density of their own populations or those of other cells in their environment, through the release of several mediators able to finely shape the cell density via coordinated changes in gene expression and protein signaling. In this regard, adenosine displays the typical characteristics of a mediator involved in the regulation of quorum sensing, thus suggesting a putative role of this nucleoside in shaping the balance between diverse immune cell populations.Graphical abstract