Comparative analysis of sesame lignans (sesamin and sesamolin) in affecting hepatic fatty acid metabolism in rats
Comparative analysis of sesame lignans (sesamin and sesamolin) in affecting hepatic fatty acid metabolism in rats
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DOI：
10.1017/s0007114507252699
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发表时间：
2007-01-01
影响因子：
3.6
通讯作者：
Ide, Takashi
中科院分区：
文献类型：
--
作者：
Lim, Jin Seon;Adachi, Yoshikazu;Ide, Takashi
比较了芝麻素和芝麻酚素（芝麻木脂素）对大鼠肝脏脂肪酸代谢的影响。给大鼠喂食无木脂素饮食、含有0.6或2 g/kg木脂素（芝麻素或芝麻林素）的饮食或含有芝麻素（1.4 g/kg）和芝麻林素（0.6 g/kg）的饮食10 d。芝麻素和芝麻林素剂量依赖性地增加参与肝脂肪酸氧化的各种酶的活性和mRNA丰度。芝麻林的增加幅度比芝麻素大得多。这些木脂素增加肝脂肪酸氧化的参数时，同时添加到实验饮食添加剂的方式。相反，它们降低了肝脂肪生成酶的活性和mRNA丰度，尽管剂量依赖性效应不一定明显。芝麻素和芝麻林在降低脂肪生成参数方面同样有效。在0.6和2 g/kg的膳食浓度下，芝麻林在血清中的累积水平分别是芝麻素的33倍和46倍。在肝脏中积累的芝麻林素的量分别是芝麻素在相应饮食水平下的10倍和7倍。芝麻林而不是芝麻素可以解释芝麻籽在增加先前观察到的肝脂肪酸氧化方面的强效生理作用。生物利用度的差异可能导致芝麻素和芝麻林对肝脂肪酸氧化的不同作用。芝麻素与芝麻林相比，在降低血清和肝脏脂质水平方面更有效，尽管芝麻林更强烈地增加肝脏脂肪酸氧化。
Effects of sesamin and sesamolin (sesame lignans) on hepatic fatty acid metabolism were compared in rats. Rats were fed either a lignan-free diet, a diet containing 0.6 or 2 g/kg lignan (sesamin or sesamolin), or a diet containing both sesamin (1.4 g/kg) and sesamolin (0.6 g/kg), for 10 d. Sesamin and sesamolin dose-dependently increased the activity and mRNA abundance of various enzymes involved in hepatic fatty acid oxidation. The increase was much greater with sesamolin than with sesamin. These lignans increased parameters of hepatic fatty acid oxidation in an additive manner when added simultaneously to an experimental diet. In contrast, they decreased the activity and mRNA abundance of hepatic lipogenic enzymes despite dose-dependent effects not being necessarily obvious. Sesamin and sesamolin were equally effective in lowering parameters of lipogenesis. Sesamolin accumulated in serum at 33- and 46-fold the level of sesamin at dietary concentrations of 0.6 and 2 g/kg, respectively. The amount of sesamolin accumulated in liver was 10- and 7-fold that of sesamin at the respective dietary levels. Sesamolin rather than sesamin can account for the potent physiological effect of sesame seeds in increasing hepatic fatty acid oxidation observed previously. Differences in bioavailability may contribute to the divergent effects of sesamin and sesamolin on hepatic fatty acid oxidation. Sesamin compared to sesamolin was more effective in reducing serum and liver lipid levels despite sesamolin more strongly increasing hepatic fatty acid oxidation.