Mechanisms regulating the ductus arteriosus
Mechanisms regulating the ductus arteriosus
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DOI：
10.1159/000092870
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发表时间：
2006-01-01
期刊：
影响因子：
--
通讯作者：
Clyman, Ronald I.
中科院分区：
文献类型：
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作者：
Clyman, Ronald I.
动脉导管未闭 (PDA) 会导致肺血流量增加并将血流重新分配到其他器官。几种合并症（即坏死性小肠结肠炎、颅内出血、肺水肿/出血、支气管肺发育不良和视网膜病变）与 PDA 的存在有关，但 PDA 是否与这些疾病的发生有关尚不清楚。在这篇综述中，对足月和早产新生儿之间的比较生理学以及防止导致 PDA 永久收缩的必要级联事件的障碍进行了综述。版权所有 (c) 2006 S. Karger AG，巴塞尔。
A patent ductus arteriosus (PDA) results in increased pulmonary blood flow and redistribution of flow to other organs. Several co-morbidities (i.e., necrotizing enterocolitis, intracranial hemorrhage, pulmonary edema/hemorrhage, bronchopulmonary dysplasia, and retinopathy) are associated with the presence of a PDA, but whether or not a PDA is responsible for their development is still unclear. In this review, comparative physiology between the full term and preterm newborn and the barriers preventing the necessary cascade of events leading to permanent constriction of the PDA are reviewed. Copyright (c) 2006 S. Karger AG, Basel.