A Review of Cell Adhesion Studies for Biomedical and Biological Applications.
A Review of Cell Adhesion Studies for Biomedical and Biological Applications.
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DOI：
10.3390/ijms160818149
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发表时间：
2015-08-05
影响因子：
5.6
通讯作者：
Ahmad MR
中科院分区：
文献类型：
--
作者：
Khalili AA;Ahmad MR
细胞粘附在细胞通讯和调节中是必不可少的，并且在组织的发育和维持中具有根本的重要性。细胞与其细胞外基质（ECM）之间的机械相互作用可以影响和控制细胞的行为和功能。细胞粘附的基本功能已经在开发用于测量和研究细胞粘附特性的方法方面产生了巨大的兴趣。细胞粘附的研究可分为细胞粘附、附着和脱离两大类。通过这两个事件，细胞粘附的研究已经被广泛探索，在细胞生物学、生物医学和工程领域中具有许多重要的目的。细胞粘附、附着和脱离事件可以进一步分为细胞群和单细胞方法。测量细胞粘附的各种技术已经应用于许多研究领域，以获得对细胞信号传导途径的理解，用于植入式传感器的生物材料研究，人工骨和牙齿替换，组织工程中的组织芯片和器官芯片的发展，生化处理和环境刺激对细胞粘附的影响，药物治疗的潜力，癌症转移研究，以及测定正常细胞和癌细胞的粘附特性。本文综述了通过附着和脱离事件研究细胞粘附的可用方法的概述。
Cell adhesion is essential in cell communication and regulation, and is of fundamental importance in the development and maintenance of tissues. The mechanical interactions between a cell and its extracellular matrix (ECM) can influence and control cell behavior and function. The essential function of cell adhesion has created tremendous interests in developing methods for measuring and studying cell adhesion properties. The study of cell adhesion could be categorized into cell adhesion attachment and detachment events. The study of cell adhesion has been widely explored via both events for many important purposes in cellular biology, biomedical, and engineering fields. Cell adhesion attachment and detachment events could be further grouped into the cell population and single cell approach. Various techniques to measure cell adhesion have been applied to many fields of study in order to gain understanding of cell signaling pathways, biomaterial studies for implantable sensors, artificial bone and tooth replacement, the development of tissue-on-a-chip and organ-on-a-chip in tissue engineering, the effects of biochemical treatments and environmental stimuli to the cell adhesion, the potential of drug treatments, cancer metastasis study, and the determination of the adhesion properties of normal and cancerous cells. This review discussed the overview of the available methods to study cell adhesion through attachment and detachment events.