NOTCH IS REQUIRED FOR WINGLESS SIGNALING IN THE EPIDERMIS OF DROSOPHILA
NOTCH IS REQUIRED FOR WINGLESS SIGNALING IN THE EPIDERMIS OF DROSOPHILA
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DOI：
10.1016/0092-8674(94)90195-3
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发表时间：
1994-10-21
期刊：
影响因子：
64.5
通讯作者：
ARIAS, AM
中科院分区：
文献类型：
--
作者：
COUSO, JP;ARIAS, AM
在果蝇的发育过程中，Notch(N)基因的突变影响许多过程。Notch的一些等位基因只影响特定的过程，这表明Notch蛋白(N)具有多个功能结构域。我们在胚胎和成体中发现了一系列N突变表型，这些表型与片段极性基因WG功能丧失所产生的表型相似。此外，我们观察到N的突变是WG的显性增强子，并且在两个基因座之间存在等位基因特异性的相互作用。我们的结果表明，WG的产物是N。
Mutations in the Notch (N) gene affect many processes during the development of Drosophila. Some alleles of Notch affect only particular processes, suggesting that the Notch protein (N) has more than one functional domain. We have found a series of N mutant phenotypes that are similar to those produced by the loss of function of the segment polarity gene wingless (wg) in the embryo and the adult. In addition, we observe that mutations in N behave as dominant enhancers of wg and that there exist allele-specific interactions between the two loci. Our results suggest that the product of wg is a ligand for N.