Immunoreactivity of Plasminogen Activator Inhibitor 1 and Its Correlation with Dysmenorrhea and Lesional Fibrosis in Adenomyosis.
Immunoreactivity of Plasminogen Activator Inhibitor 1 and Its Correlation with Dysmenorrhea and Lesional Fibrosis in Adenomyosis.
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子宫腺肌病纤溶酶原激活剂抑制剂1的免疫反应性及其与痛经和病灶纤维化的相关性
DOI：
10.1007/s43032-021-00513-6
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发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
Xu H
中科院分区：
文献类型：
--
作者：
Yang B;Gu N;Shi S;Zhang C;Chen L;Ouyang J;Lin Y;Sun F;Xu H
子宫腺肌症与痛经、不孕症和病变纤维化有关。子宫腺肌症的发病机制尚不清楚。纤溶酶原激活物抑制剂1 （PAI-1）在肿瘤转移、子宫内膜异位症等病理活动中起重要作用。我们的目的是研究PAI-1在伴有子宫腺肌症的异位和异位子宫内膜以及不伴有子宫腺肌症的子宫内膜中的表达和定位。我们还试图确定PAI-1免疫反应性与痛经严重程度和子宫腺肌症病变纤维化程度之间的关系。PAI-1在子宫腺肌症患者异位子宫内膜中的表达明显高于子宫腺肌症患者异位子宫内膜和对照子宫内膜。异位PAI-1表达与痛经视觉模拟评分（VAS）评分及子宫腺肌症病变纤维化程度呈正相关。PAI-1高表达增加了子宫腺肌症患者出现中重度痛经的可能性。这些结果表明PAI-1参与了腺肌病相关的痛经和病变纤维化，这为治疗症状性bbb提供了潜在的靶点。
Adenomyosis is associated with dysmenorrhea, infertility, and lesional fibrosis. The pathogenesis of adenomyosis is still unclear. Plasminogen activator inhibitor 1 (PAI-1) plays important roles in pathological activities like tumor metastasis and endometriosis. Our objective was to investigate the expression and localization of PAI-1 in eutopic and ectopic endometrium with adenomyosis and in endometrium without adenomyosis. We also sought to determine the relationship between PAI-1 immunoreactivity and the severity of dysmenorrhea and the extent of lesional fibrosis in adenomyosis. PAI-1 expression was significantly higher in the ectopic endometrium of patients with adenomyosis than in both the eutopic endometrium of patients with adenomyosis and the endometrium of controls. Ectopic PAI-1 expression correlated positively with dysmenorrhea visual analog scale (VAS) scores and the extent of lesional fibrosis in adenomyosis. High PAI-1 expression increased the likelihood of moderate to severe dysmenorrhea in adenomyosis. These results suggest that PAI-1 is involved in the adenomyosis-associated dysmenorrhea and lesional fibrosis, which provide a potential target in treating symptomatic adenomyosis.
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