Chest Radiograph Thoracic Areas and Lung Volumes in Infants Developing Bronchopulmonary Dysplasia
Chest Radiograph Thoracic Areas and Lung Volumes in Infants Developing Bronchopulmonary Dysplasia
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DOI：
10.1002/ppul.20952
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发表时间：
2009-01-01
影响因子：
3.1
通讯作者：
Greenough, Anne
中科院分区：
文献类型：
--
作者：
May, Caroline;Prendergast, Michael;Greenough, Anne
目的：确定是否胸部X线片（CXR）的胸部面积和肺体积之间有差异，并根据BPD的严重程度，有和没有发展BPD的婴儿。工作假设：发生BPD的婴儿，特别是中度或重度BPD的婴儿，在围产期会有低的CXR胸面积和肺体积。研究设计：前瞻性研究患者-受试者选择：53例中位胎龄为28周（范围24-32周）的婴儿。方法学：使用图片存档和通信系统（PACS）计算CXR胸部面积，并通过测量出生后前72小时的功能残气量（FRC）评估肺容量。如果婴儿在28天后仍有氧依赖性，则诊断为BPD，在月经后36周（PMA）时不再有氧依赖性的婴儿中诊断为轻度BPD，在36周PMA时需要补充氧气伴或不伴呼吸支持的婴儿中诊断为中度/重度BPD。结果：32例患儿发生BPD，中、重度BPD 21例。与无BPD婴儿相比，BPD婴儿的中位数CXR胸部面积较高（P <0.0001），FRC较低（P < 0.0001）。中、重度BPD组CXR胸廓面积中位数（P < 0.001）和轻度BPD组（P < 0.05）均大于非BPD组，中、重度BPD组FRC中位数（P < 0.001）和轻度BPD组（P < 0.05）均小于非BPD组。结论：这些结果强调，在围产期婴儿发展BPD，特别是如果模式率/严重，具有低功能肺容量，并可能有气体捕获，这可能反映通气不均匀性。小儿肺醇。2009;44：80-85. (c)2008 Wiley-Liss，Inc.
Objectives: To determine whether chest radiograph (CXR) thoracic areas and lung volumes differed between infants who did and did not develop BPD and according to the severity of BPD developed. Working Hypothesis: Infants developing BPD, particularly if moderate or severe, would have low CXR thoracic areas and lung volumes in the perinatal period. Study Design: Prospective study Patient-Subject Selection: 53 infants with a median gestational age of 28 (range 24-32) weeks. Methodology: CXR thoracic areas were calculated using a Picture Archiving and Communicating System (PACS) and lung volume assessed by measurement of functional residual capacity (FRC) in the first 72 hr after birth. BPD was diagnosed if the infants were oxygen dependent beyond 28 days, mild BPD in infants no longer oxygen dependent at 36 weeks post-menstrual age (PMA) and moderate/severe BPD in infants who required supplementary oxygen with or without respiratory support at 36 weeks PMA. Results: Thirty two infants developed BPD, 21 had moderate/severe BPD. The median CXR thoracic areas were higher (P < 0.0001) and FRCs were lower (P < 0.0001) in the BPD compared to no BPD infants. The median CXR thoracic areas of the moderate/severe group (P < 0.001) and the mild group (P < 0.05) were greater than that of the no BPD group and the median FRC of the moderate/severe BPD group was lower than the no BPD group (< 0.001) and the mild BPD group (P < 0.05). Conclusion: These results highlight that in the perinatal period infants developing BPD, particularly if mode rate/severe, have low functional lung volumes and may have gas trapping, which likely reflects ventilation inhomogeneity. Pediatr Pulmonol. 2009;44:80-85. (c) 2008 Wiley-Liss, Inc.