British Thoracic Society guidelines for the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD)
British Thoracic Society guidelines for the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD)
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DOI：
10.1136/thoraxjnl-2017-210927
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发表时间：
2017-01-01
期刊：
影响因子：
10
通讯作者：
Floto, R. Andres
中科院分区：
文献类型：
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作者：
Haworth, Charles S.;Banks, John;Floto, R. Andres
自2000年英国胸科学会(BTS)发表《机会性分枝杆菌感染管理指南》以来，我们对非结核分枝杆菌-肺部疾病(NTM-PD)的流行病学、微生物学和治疗有了进一步的了解。3 NTM-PD的发病率和患病率正在增加，很可能是由于临床医生意识的提高和检测方法的改进，以及各种不断变化的环境、分枝杆菌和宿主因素。分子微生物学的技术进步彻底改变了我们对NTM分类学的理解，现在人们认识到，物种和亚种的致病性和治疗反应往往不同。虽然仍然缺乏当代随机对照试验数据来为实践提供信息，但指南开发小组已寻求将可用的最佳证据与临床经验相结合，以创建实用的管理指南。
BackgroundSince the publication of the British Thoracic Society (BTS) Guideline on the ‘Management of opportunistic mycobacterial infections’ in 2000, our understanding of the epidemiology, microbiology and management of non-tuberculous mycobacterial-pulmonary disease (NTM-PD) has advanced. 3 The incidence and prevalence of NTM-PD are increasing and are most likely explained by improved clinician awareness and enhanced detection methods, as well as a variety of changing environmental, mycobacterial and host factors. Technological advances in molecular microbiology have revolutionised our understanding of NTM taxonomy, and it is now appreciated that species and subspecies often differ in their pathogenicity and treatment response. While there remains a dearth of contemporary randomised controlled trial data to inform practice, the Guideline Development Group has sought to combine the best available evidence with clinical experience to create a pragmatic management guideline.