Regulation of nerve growth factor mRNA by interleukin-1 in rat hippocampal astrocytes is mediated by NF kappa B
Regulation of nerve growth factor mRNA by interleukin-1 in rat hippocampal astrocytes is mediated by NF kappa B
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DOI：
10.1074/jbc.271.49.31115
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发表时间：
1996-12-06
影响因子：
4.8
通讯作者：
Rabson, AB
中科院分区：
文献类型：
--
作者：
Friedman, WJ;Thakur, S;Rabson, AB
细胞因子如白细胞介素-1 β（IL-1）在发育期间和由病变或疾病引起的炎症过程期间在脑中产生。IL-1在脑中的一个功能似乎是刺激星形胶质细胞增殖并产生多种细胞因子和营养因子，包括神经生长因子。IL-1对星形胶质细胞发挥作用的机制仍不清楚。我们目前的证据表明，这种细胞因子elevening激活NF κ B B转录因子，这种转录因子介导的影响IL-1对神经生长因子mRNA的表达。阐明细胞因子激活星形胶质细胞和影响营养因子表达的过程可能会提供洞察中枢神经系统内的炎症过程的机制。
Cytokines such as interleukin-1 beta (IL-1) are produced in the brain during development and during inflammatory processes that result from lesions or disease. One function of IL-1 in the brain appears to be the stimulation of astrocytes to proliferate and produce a variety of cytokines and trophic factors, including nerve growth factor. The mechanisms by which IL-1 exerts its actions on astrocytes remain poorly defined. We present evidence that this cytokine elicits activation of the NF kappa B transcription factor and that this transcription factor mediates effects of Il-1 on nerve growth factor mRNA expression. Elucidation of the processes by which cytokines activate astrocytes and influence trophic factor expression may provide insight into mechanisms governing inflammatory processes within the central nervous system.