Aromatic ring favorable and efficient H-D exchange reaction catalyzed by Pt/C
Aromatic ring favorable and efficient H-D exchange reaction catalyzed by Pt/C
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DOI：
10.1016/j.tetlet.2005.08.067
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发表时间：
2005-10-10
影响因子：
1.8
通讯作者：
Hirota, K
中科院分区：
文献类型：
--
作者：
Sajiki, H;Ito, N;Hirota, K
发展了一种在氢气气氛下以D2 O为氘源的Pt/C催化芳环氘代反应方法。5%的Pt/C将导致在芳环系统上相当有效的H-D交换结果。该反应对于包括生物活性化合物在内的各种芳族化合物是通用的。(c)2005爱思唯尔有限公司保留所有权利。
An effective and applicable Pt/C-catalyzed deuteration method of aromatic rings using D2O as a deuterium source under hydrogen atmosphere was developed. Five percent Pt/C would lead to quite effective H-D exchange results on the aromatic ring systems. The reaction is general for a variety of aromatic compounds including biologically active compounds. (c) 2005 Elsevier Ltd. All rights reserved.