Vascularized Fibular Flaps Enhance Histological Repair in Pasteurized Autogenous Bone Graft
Vascularized Fibular Flaps Enhance Histological Repair in Pasteurized Autogenous Bone Graft
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带血管的腓骨瓣增强巴氏灭菌自体骨移植物的组织学修复
DOI：
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发表时间：
2011
影响因子：
1.5
通讯作者：
N. Ishiguro
中科院分区：
文献类型：
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作者：
Y. Nishida;S. Tsukushi;J. Wasa;H. Urakawa;K. Toriyama;Y. Kamei;N. Ishiguro
结构性巴氏灭菌自体骨移植的愈合过程尚未详细研究。本研究的目的是从组织学上评估巴氏消毒骨移植的修复过程，并阐明影响结果的因素。自1992年以来，在51例应用灭菌自体骨移植的患者中，取10例胫骨或股骨重建下肢后的标本，同时进行腓骨瓣或不同时进行腓骨瓣移植，并进行分析。移植骨的再生评估为活细胞数与全细胞数的比率。巴氏消毒骨结合带血管腓骨显示出明显更好的修复。从植入到取出的时间较长与带血管腓骨的修复过程更好相关（P = 0.03），而其他因素无显著影响。这项研究表明，巴氏灭菌自体骨移植物保持结构稳定多年，虽然促进者，如血管化腓骨的联合使用，需要促进移植物的再生。
The healing process of structural pasteurized autogenous bone graft has not been studied in detail. The purpose of this investigation was to assess the reparative process of pasteurized bone graft histologically, and clarify the factors influencing the outcome. From among 51 cases using pasteurized autogenous bone graft since 1992, 10 specimens were retrieved after lower extremity reconstruction of tibia or femur with or without simultaneous fibula flap, and subjected to the analysis. Regeneration of the grafted bone was assessed as the ratio of the number of viable cells to that of whole cells. Pasteurized bone combined with a vascularized fibula showed markedly better repair. Long duration from implantation to retrieval was associated with a better reparative process with vascularized fibula (P = 0.03), whereas other factors had no significant impact. This study demonstrated that pasteurized autogenous bone graft remained structurally stable for many years, although facilitators such as the combined use of a vascularized fibula are required to promote regeneration of the graft.